Anti-SHC3 Antibody (CAB15453)
- SKU:
- CAB15453
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Frequently bought together:
Description
抗体名: | Anti-SHC3 Antibody |
抗体コード: | CAB15453 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 310-450 of human SHC3 (NP_058544.3). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:2000 |
反応性: | Mouse |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 310-450 of human SHC3 (NP_058544.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | QCPT KIPA LHDR MQSL DEPW TEEE GDGS DHPY YNSI PSKM PPPG GFLD TRLK PRPH APDT AQFA GKEQ TYYQ GRHL GDTF GEDW QQTP LRQG SSDI YSTP EGKL HVAP TGEA PTYV NTQQ IPPQ AWPA AVSS AESS PRKD L |
遺伝子ID: | 53358 |
Uniprot: | Q92529 |
セルラーロケーション: | |
計算された分子量: | 51kDa/64kDa |
観察された分子量: | Refer to figures |
同義語: | SHC3, N-Shc, NSHC, RAI, SHCC |
バックグラウンド: |
UniProt Protein Function: | SHC3: an adapter protein containing an SH2 and a PID domain. Couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons and the regulation of NMDA receptor function in the hippocampus. May modulate hippocampal synaptic plasticity underlying learning and memory. Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. A switch from Shc1 to Shc3 occurs during maturation of neuronal precursors to postmitotic neurons. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 9q22.1 Cellular Component: plasma membrane; cytosol Molecular Function:signal transducer activity; protein binding; receptor tyrosine kinase binding; protein kinase binding Biological Process: epidermal growth factor receptor signaling pathway; synaptic transmission, glutamatergic; central nervous system development; learning and/or memory; nerve growth factor receptor signaling pathway; Ras protein signal transduction; insulin receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway |
UniProt Code: | Q92529 |
NCBI GenInfo Identifier: | 224586793 |
NCBI Gene ID: | 53358 |
NCBI Accession: | NP_058544.3 |
UniProt Secondary Accession: | Q92529,Q5T7I7, Q8TAP2, Q9UCX5, |
UniProt Related Accession: | Q92529 |
Molecular Weight: | 64,056 Da |
NCBI Full Name: | SHC-transforming protein 3 |
NCBI Synonym Full Names: | SHC (Src homology 2 domain containing) transforming protein 3 |
NCBI Official Symbol: | SHC3 |
NCBI Official Synonym Symbols: | RAI; NSHC; SHCC; N-Shc |
NCBI Protein Information: | SHC-transforming protein 3; protein Rai; neuronal Shc; SH2 domain protein C3; SHC-transforming protein C; src homology 2 domain-containing transforming protein C3; src homology 2 domain-containing-transforming protein C3 |
UniProt Protein Name: | SHC-transforming protein 3 |
UniProt Synonym Protein Names: | Neuronal Shc; N-Shc; Protein Rai; SHC-transforming protein C; Src homology 2 domain-containing-transforming protein C3 |
Protein Family: | SHC-transforming protein |
UniProt Gene Name: | SHC3 |
UniProt Entry Name: | SHC3_HUMAN |
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