Anti-SGMS1 Antibody (CAB15008)
- SKU:
- CAB15008
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
抗体名: | Anti-SGMS1 Antibody |
抗体コード: | CAB15008 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human SGMS1 (NP_671512.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Rat |
ポジティブサンプル: | A-549 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human SGMS1 (NP_671512.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MKEV VYWS PKKV ADWL LENA MPEY CEPL EHFT GQDL INLT QEDF KKPP LCRV SSDN GQRL LDMI ETLK MEHH LEAH KNGH ANGH LNIG VDIP TPDG SFSI KIKP NGMP NGYR KEMI KIPM PELE RSQY PMEW GK |
遺伝子ID: | 259230 |
Uniprot: | Q86VZ5 |
セルラーロケーション: | Golgi apparatus membrane, Multi-pass membrane protein |
計算された分子量: | 25kDa/49kDa |
観察された分子量: | 49kDa |
同義語: | SGMS1, MOB, MOB1, SMS1, TMEM23, hmob33 |
バックグラウンド: | The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain. |
UniProt Protein Function: | TMEM23: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Belongs to the sphingomyelin synthase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; EC 2.7.8.27; Membrane protein, integral; Lipid Metabolism - sphingolipid; Transferase Chromosomal Location of Human Ortholog: 10q11.2 Cellular Component: Golgi membrane; membrane; endoplasmic reticulum; Golgi trans cisterna; plasma membrane; integral to Golgi membrane; nucleus Molecular Function:sphingomyelin synthase activity; kinase activity; ceramide cholinephosphotransferase activity Biological Process: sphingolipid metabolic process; sphingolipid biosynthetic process; apoptosis; cell growth; sphingomyelin biosynthetic process; inflammatory response; phosphorylation |
NCBI Summary: | The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q86VZ5 |
NCBI GenInfo Identifier: | 44888473 |
NCBI Gene ID: | 259230 |
NCBI Accession: | Q86VZ5.2 |
UniProt Secondary Accession: | Q86VZ5,Q68U43, Q6EKK0, Q75SP1, |
UniProt Related Accession: | Q86VZ5 |
Molecular Weight: | 419 |
NCBI Full Name: | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
NCBI Synonym Full Names: | sphingomyelin synthase 1 |
NCBI Official Symbol: | SGMS1 |
NCBI Official Synonym Symbols: | MOB; MOB1; SMS1; TMEM23; hmob33 |
NCBI Protein Information: | phosphatidylcholine:ceramide cholinephosphotransferase 1; protein Mob; transmembrane protein 23; medulla oblongata-derived protein |
UniProt Protein Name: | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
UniProt Synonym Protein Names: | Medulla oblongata-derived protein; Protein Mob; Sphingomyelin synthase 1; Transmembrane protein 23 |
UniProt Gene Name: | SGMS1 |
UniProt Entry Name: | SMS1_HUMAN |
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