Anti-SGCA Antibody (CAB4109)
- SKU:
- CAB4109
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-SGCA Antibody |
抗体コード: | CAB4109 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-290 of human SGCA (NP_000014.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A-549, LO2, 293T, Mouse skeletal muscle, Mouse heart, Rat skeletal muscle, Rat heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-290 of human SGCA (NP_000014.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ITYH AHLQ GHPD LPRW LRYT QRSP HHPG FLYG SATP EDRG LQVI EVTA YNRD SFDT TRQR LVLE IGDP EGPL LPYQ AEFL VRSH DAEE VLPS TPAS RFLS ALGG LWEP GELQ LLNV TSAL DRGG RVPL PIEG RKEG VYIK VGSA SPFS TCLK MVAS PDSH ARCA QGQP PLLS CYDT LAPH FRVD WCNV TLVD KSVP EPAD EVPT PGDG ILEH DPFF CPPT EAPD RDFL VDA |
遺伝子ID: | 6442 |
Uniprot: | Q16586 |
セルラーロケーション: | Cell membrane, Cytoplasm, Single-pass type I membrane protein, cytoskeleton, sarcolemma |
計算された分子量: | 29kDa/42kDa |
観察された分子量: | 43kDa |
同義語: | SGCA, 50DAG, ADL, DAG2, DMDA2, LGMD2D, SCARMD1, adhalin |
バックグラウンド: | This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | SGCA: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCA are the cause of limb-girdle muscular dystrophy type 2D (LGMD2D); also known as Duchenne- like muscular dystrophy autosomal recessive type 2 or severe childhood autosomal recessive muscular dystrophy (SCARMD). LGMD2D is an autosomal recessive degenerative myopathy characterized by progressive muscle wasting from early childhood with loss of independent ambulation by teenage years. Muscle biopsy shows necrosis, decreased immunostaining for alpha sarcoglycan, and adhalin deficiency. The phenotype is less severe than LGMD2C. Belongs to the sarcoglycan alpha/epsilon family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q21 Cellular Component: dystrophin-associated glycoprotein complex; sarcoglycan complex Molecular Function:protein binding Biological Process: muscle contraction; muscle development Disease: Muscular Dystrophy, Limb-girdle, Type 2d |
NCBI Summary: | This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
UniProt Code: | Q16586 |
NCBI GenInfo Identifier: | 13431858 |
NCBI Gene ID: | 6442 |
NCBI Accession: | Q16586.1 |
UniProt Secondary Accession: | Q16586,Q13710, Q13712, A6NEB8, A8K3K7, |
UniProt Related Accession: | Q16586 |
Molecular Weight: | 29,354 Da |
NCBI Full Name: | Alpha-sarcoglycan |
NCBI Synonym Full Names: | sarcoglycan alpha |
NCBI Official Symbol: | SGCA |
NCBI Official Synonym Symbols: | ADL; DAG2; 50DAG; DMDA2; LGMD2D; SCARMD1; adhalin |
NCBI Protein Information: | alpha-sarcoglycan |
UniProt Protein Name: | Alpha-sarcoglycan |
UniProt Synonym Protein Names: | 50 kDa dystrophin-associated glycoprotein; 50DAG; Adhalin; Dystroglycan-2 |
Protein Family: | Alpha-sarcoglycan |
UniProt Gene Name: | SGCA |
UniProt Entry Name: | SGCA_HUMAN |
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