Anti-SET1A Antibody (CAB18231)
- SKU:
- CAB18231
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-SET1A Antibody |
抗体コード: | CAB18231 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human SET1A. |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa, Jurkat, HepG2, U-251MG, Mouse testis |
免疫原: | Recombinant protein of human SET1A. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 9739 |
Uniprot: | O15047 |
セルラーロケーション: | |
計算された分子量: | 186kDa |
観察された分子量: | 300kDa |
同義語: | Set1, KMT2F, Set1A, SETD1A, SET1A |
バックグラウンド: | The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. |
UniProt Protein Function: | SETD1A: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: histone methyltransferase complex; nuclear chromatin; nuclear speck; nucleoplasm; nucleus Molecular Function:beta-catenin binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding; transcription factor binding |
NCBI Summary: | The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Dec 2016] |
UniProt Code: | O15047 |
NCBI GenInfo Identifier: | 749385041 |
NCBI Gene ID: | 9739 |
NCBI Accession: | NM_014712.2 |
UniProt Secondary Accession: | O15047,Q6PIF3, Q8TAJ6, A6NP62, |
UniProt Related Accession: | O15047 |
Molecular Weight: | ~61 kDa |
NCBI Full Name: | Homo sapiens SET domain containing 1A (SETD1A), mRNA |
NCBI Synonym Full Names: | SET domain containing 1A |
NCBI Official Symbol: | SETD1A |
NCBI Official Synonym Symbols: | Set1; KMT2F; Set1A |
NCBI Protein Information: | histone-lysine N-methyltransferase SETD1A |
UniProt Protein Name: | Histone-lysine N-methyltransferase SETD1A |
UniProt Synonym Protein Names: | Lysine N-methyltransferase 2F; SET domain-containing protein 1A; hSET1A; Set1/Ash2 histone methyltransferase complex subunit SET1 |
UniProt Gene Name: | SETD1A |