Anti-SEMA6D Antibody (CAB14935)
- SKU:
- CAB14935
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-SEMA6D Antibody |
抗体コード: | CAB14935 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human SEMA6D (NP_705871.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human SEMA6D (NP_705871.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | AVSF PEDD EPLN TVDY HYSR QYPV FRGR PSGN ESQH RLDF QLML KIRD TLYI AGRD QVYT VNLN EMPK TEVI PNKK LTWR SRQQ DREN CAM |
遺伝子ID: | 80031 |
Uniprot: | Q8NFY4 |
セルラーロケーション: | Cell membrane, Cytoplasm, Single-pass type I membrane protein |
計算された分子量: | 54kDa/67kDa/111-119kDa |
観察された分子量: | Refer to figures |
同義語: | SEMA6D |
バックグラウンド: | Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. |
UniProt Protein Function: | SEMA6D: a single-pass type I membrane protein of the semaphorin family that shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Seven alternatively spliced human isoforms have been reported. All are intrinsic membrane proteins except isoform 7, which is cytoplasmic. |
UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q21.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:chemorepellent activity; semaphorin receptor binding Biological Process: negative regulation of axon extension involved in axon guidance; neural crest cell migration; positive regulation of cell migration |
NCBI Summary: | Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010] |
UniProt Code: | Q8NFY4 |
NCBI GenInfo Identifier: | 74715611 |
NCBI Gene ID: | 80031 |
NCBI Accession: | Q8NFY4.1 |
UniProt Secondary Accession: | Q8NFY4,Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249, A6NF10 A6NM95, A6NNK1, A7E2A0, |
UniProt Related Accession: | Q8NFY4 |
Molecular Weight: | 67,538 Da |
NCBI Full Name: | Semaphorin-6D |
NCBI Synonym Full Names: | semaphorin 6D |
NCBI Official Symbol: | SEMA6D |
NCBI Protein Information: | semaphorin-6D |
UniProt Protein Name: | Semaphorin-6D |
Protein Family: | Semaphorin |
UniProt Gene Name: | SEMA6D |
UniProt Entry Name: | SEM6D_HUMAN |
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