Anti-SCN3A Antibody (CAB10072)
- SKU:
- CAB10072
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-SCN3A Antibody |
抗体コード: | CAB10072 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 274-400 of human SCN3A (NP_008853.3). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:1000 |
反応性: | Human |
ポジティブサンプル: | 293T, HT-1080 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 274-400 of human SCN3A (NP_008853.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | RNKC LQWP PSDS AFET NTTS YFNG TMDS NGTF VNVT MSTF NWKD YIGD DSHF YVLD GQKD PLLC GNGS DAGQ CPEG YICV KAGR NPNY GYTS FDTF SWAF LSLF RLMT QDYW ENLY QLTL RAAG KTY |
遺伝子ID: | 6328 |
Uniprot: | Q9NY46 |
セルラーロケーション: | Membrane, Multi-pass membrane protein |
計算された分子量: | 221kDa/226kDa |
観察された分子量: | 350kDa |
同義語: | SCN3A, NAC3, Nav1.3 |
バックグラウンド: | Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | SCN3A: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, sodium; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 2q24 Cellular Component: voltage-gated sodium channel complex; cytoplasm; plasma membrane Molecular Function:voltage-gated sodium channel activity Biological Process: sodium ion transport; generation of action potential |
NCBI Summary: | Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NY46 |
NCBI GenInfo Identifier: | 126362955 |
NCBI Gene ID: | 6328 |
NCBI Accession: | NP_001075146.1 |
UniProt Secondary Accession: | Q9NY46,Q16142, Q53SX0, Q9BZB3, Q9C006, Q9NYK2, Q9P2J1 Q9UPD1, Q9Y6P4, |
UniProt Related Accession: | Q9NY46 |
Molecular Weight: | 226,294 Da |
NCBI Full Name: | sodium channel protein type 3 subunit alpha isoform 3 |
NCBI Synonym Full Names: | sodium channel, voltage-gated, type III, alpha subunit |
NCBI Official Symbol: | SCN3A |
NCBI Official Synonym Symbols: | NAC3; Nav1.3 |
NCBI Protein Information: | sodium channel protein type 3 subunit alpha; brain III voltage-gated sodium channel; voltage-gated sodium channel subtype III; sodium channel protein type III subunit alpha; sodium channel protein brain III subunit alpha; voltage-gated sodium channel subunit alpha Nav1.3; sodium channel, voltage-gated, type III, alpha polypeptide |
UniProt Protein Name: | Sodium channel protein type 3 subunit alpha |
UniProt Synonym Protein Names: | Sodium channel protein brain III subunit alpha; Sodium channel protein type III subunit alpha; Voltage-gated sodium channel subtype III; Voltage-gated sodium channel subunit alpha Nav1.3 |
Protein Family: | Sodium channel protein |
UniProt Gene Name: | SCN3A |
UniProt Entry Name: | SCN3A_HUMAN |
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