Anti-SCARB2 抗体 (CAB12723)

抗体名:	Anti-SCARB2 Antibody
抗体コード:	CAB12723
抗体サイズ:	20uL, 50uL, 100uL
申し込み:	WB
反応性:	Human, Mouse, Rat
宿主種:	Rabbit
免疫原:	Recombinant fusion protein containing a sequence corresponding to amino acids 200-380 of human SCARB2 (NP_005497.1).

申し込み:	WB
推奨希釈:	WB 1:1000 - 1:3000
反応性:	Human, Mouse, Rat
ポジティブサンプル:	HeLa, HepG2, Mouse heart, Mouse Lung, Mouse Liver, Rat Lung

免疫原:	Recombinant fusion protein containing a sequence corresponding to amino acids 200-380 of human SCARB2 (NP_005497.1).
精製方法:	Affinity purification
ストレージバッファ:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:	IgG
順序:	GLFY EKNG TNDG DYVF LTGE DSYL NFTK IVEW NGKT SLDW WITD KCNM INGT DGDS FHPL ITKD EVLY VFPS DFCR SVYI TFSD YESV QGLP AFRY KVPA EILA NTSD NAGF CIPE GNCL GSGV LNVS ICKN GAPI IMSF PHFY QADE RFVS AIEG MHPN QEDH ETFV DINP LTGI ILKA A
遺伝子ID:	950
Uniprot:	Q14108
セルラーロケーション:	Lysosome membrane, Multi-pass membrane protein
計算された分子量:	37kDa/54kDa
観察された分子量:	80kDa

同義語:

SCARB2, AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII

バックグラウンド:

The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	SCARB2: Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. Defects in SCARB2 are the cause of progressive myoclonic epilepsy type 4 with or without renal failure (EPM4). An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. Cognitive function is preserved. Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease. Belongs to the CD36 family.
UniProt Protein Details:	Protein type:Receptor, misc.; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 4q21.1 Cellular Component: lysosomal lumen; focal adhesion; membrane; lysosomal membrane; integral to membrane Molecular Function:protein binding; enzyme binding; receptor activity Biological Process: protein targeting to lysosome; cell adhesion Disease: Epilepsy, Progressive Myoclonic 4, With Or Without Renal Failure
NCBI Summary:	The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
UniProt Code:	Q14108
NCBI GenInfo Identifier:	2498525
NCBI Gene ID:	950
NCBI Accession:	Q14108.2
UniProt Secondary Accession:	Q14108,O35114, P27615,
UniProt Related Accession:	Q14108
Molecular Weight:	54,290 Da
NCBI Full Name:	Lysosome membrane protein 2
NCBI Synonym Full Names:	scavenger receptor class B, member 2
NCBI Official Symbol:	SCARB2
NCBI Official Synonym Symbols:	AMRF; EPM4; LGP85; CD36L2; HLGP85; LIMP-2; LIMPII; SR-BII
NCBI Protein Information:	lysosome membrane protein 2; LIMP II; CD36 antigen-like 2; lysosome membrane protein II; 85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2; CD36 antigen (collagen type I receptor, thrombos
UniProt Protein Name:	Lysosome membrane protein 2
UniProt Synonym Protein Names:	85 kDa lysosomal membrane sialoglycoprotein; LGP85; CD36 antigen-like 2; Lysosome membrane protein II; LIMP II; Scavenger receptor class B member 2
Protein Family:	Platelet glycoprotein
UniProt Gene Name:	SCARB2
UniProt Entry Name:	SCRB2_HUMAN

Western blot analysis of extracts of various cell lines, using SCARB2 antibody (CAB12723) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies

Anti-SCARB2 Antibody (CAB6285)

Anti-LIMPII Antibody (CAB9185)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)