Anti-SARS2 Antibody (CAB12297)
- SKU:
- CAB12297
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-SARS2 Antibody |
抗体コード: | CAB12297 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 289-518 of human SARS2 (NP_060297.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HepG2, Mouse liver, Mouse kidney |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 289-518 of human SARS2 (NP_060297.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ARFK DLNL AGTA EVGL AGYF MDHT VAFR DLPV RMVC SSTC YRAE TNTG QEPR GLYR VHHF TKVE MFGV TGPG LEQS SQLL EEFL SLQM EILT ELGL HFRV LDMP TQEL GLPA YRKF DIEA WMPG RGRF GEVT SASN CTDF QSRR LHIM FQTE AGEL QFAH TVNA TACA VPRL LIAL LESN QQKD GSVL VPPA LQSY LGTD RITA PTHV PLQY IGPN QPRK PGLP GQPA VS |
遺伝子ID: | 54938 |
Uniprot: | Q9NP81 |
セルラーロケーション: | Mitochondrion matrix |
計算された分子量: | 58kDa |
観察された分子量: | 50kDa |
同義語: | SARS2, SARS, SARSM, SERS, SYS, SerRS, SerRSmt |
バックグラウンド: | This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. |
UniProt Protein Function: | SARS2: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). Defects in SARS2 are the cause of hyperuricemia pulmonary hypertension renal failure and alkalosis (HUPRA). HUPRA is a multisystem disorder characterized by onset in infancy of progressive renal failure leading to electrolyte imbalances, metabolic alkalosis, pulmonary hypertension, hypotonia, and delayed development. Affected individuals are born prematurely. Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial; Translation; Ligase; EC 6.1.1.11 Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: cytoplasm; mitochondrial matrix; mitochondrion Molecular Function:ATP binding; serine-tRNA ligase activity Biological Process: seryl-tRNA aminoacylation; tRNA aminoacylation for protein translation Disease: Hyperuricemia, Pulmonary Hypertension, Renal Failure, And Alkalosis |
NCBI Summary: | This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009] |
UniProt Code: | Q9NP81 |
NCBI GenInfo Identifier: | 23822219 |
NCBI Gene ID: | 54938 |
NCBI Accession: | Q9NP81.1 |
UniProt Secondary Accession: | Q9NP81,Q9BVP3, A6NHW7, B4DE10, |
UniProt Related Accession: | Q9NP81 |
Molecular Weight: | 58,030 Da |
NCBI Full Name: | Serine--tRNA ligase, mitochondrial |
NCBI Synonym Full Names: | seryl-tRNA synthetase 2, mitochondrial |
NCBI Official Symbol: | SARS2 |
NCBI Official Synonym Symbols: | SYS; SARS; SERS; SARSM; SerRS; SerRSmt; mtSerRS |
NCBI Protein Information: | serine--tRNA ligase, mitochondrial |
UniProt Protein Name: | Serine--tRNA ligase, mitochondrial |
UniProt Synonym Protein Names: | SerRSmt; Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetase |
UniProt Gene Name: | SARS2 |
UniProt Entry Name: | SYSM_HUMAN |
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