Anti-SAP18 Antibody (CAB4397)
- SKU:
- CAB4397
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- SAP18
- Synonyms:
- 2HOR0202
- Synonyms:
- SAP18P
Frequently bought together:
Description
抗体名: | SAP18 Rabbit pAb |
抗体コード: | CAB4397 |
サイズ: | 20uL, 50uL, 100uL |
同義語: | SAP18, 2HOR0202, SAP18P |
申し込み: | WB, IHC, IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-172 of human SAP18 (NP_005861.2). |
申し込み: | WB, IHC, IF |
推奨される希釈: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SW480 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-172 of human SAP18 (NP_005861.2). |
精製方法: | Affinity purification |
保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | AVES RVTQ EEIK KEPE KPID REKT CPLL LRVF TTNN GRHH RMDE FSRG NVPS SELQ IYTW MDAT LKEL TSLV KEVY PEAR KKGT HFNF AIVF TDVK RPGY RVKE IGST MSGR KGTD DSMT LQSQ KFQI GDYL DIAI TPPN RAPP PSGR MRPY |
遺伝子ID: | 10284 |
Uniprot: | O00422 |
セルラーロケーション: | Cytoplasm, Nucleus, Nucleus speckle |
計算された分子量: | 17kDa |
観察された分子量: | 18kDa |
UniProt Protein Function: | SAP18: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Belongs to the SAP18 family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 13q12.11 Cellular Component: nucleoplasm; histone deacetylase complex; cytoplasm; nuclear speck Molecular Function:protein binding; transcription corepressor activity Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; negative regulation of nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; negative regulation of gene expression, epigenetic; positive regulation of apoptosis; RNA splicing; gene expression; mRNA processing; regulation of gene expression, epigenetic; regulation of alternative nuclear mRNA splicing, via spliceosome |
NCBI Summary: | Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008] |
UniProt Code: | O00422 |
NCBI GenInfo Identifier: | 6831678 |
NCBI Gene ID: | 10284 |
NCBI Accession: | O00422.1 |
UniProt Related Accession: | O00422 |
Molecular Weight: | |
NCBI Full Name: | Histone deacetylase complex subunit SAP18 |
NCBI Synonym Full Names: | Sin3A associated protein 18 |
NCBI Official Symbol: | SAP18 |
NCBI Official Synonym Symbols: | SAP18P; 2HOR0202 |
NCBI Protein Information: | histone deacetylase complex subunit SAP18 |
UniProt Protein Name: | Histone deacetylase complex subunit SAP18 |
UniProt Synonym Protein Names: | 18 kDa Sin3-associated polypeptide; 2HOR0202; Cell growth-inhibiting gene 38 protein; Sin3-associated polypeptide p18 |
Protein Family: | Zinc finger A20 domain-containing stress-associated protein |
UniProt Gene Name: | SAP18 |
UniProt Entry Name: | SAP18_HUMAN |