Anti-RXRG Antibody (CAB1877)
- SKU:
- CAB1877
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-RXRG Antibody |
抗体コード: | CAB1877 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-137 of human RXRG (NP_008848.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Jurkat, DU145, U-87MG, Mouse brain, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-137 of human RXRG (NP_008848.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MYGN YSHF MKFP AGYG GSPG HTGS TSMS PSAA LSTG KPMD SHPS YTDT PVSA PRTL SAVG TPLN ALGS PYRV ITSA MGPP SGAL AAPP GINL VAPP SSQL NVVN SVSS SEDI KPLP GLPG IGNM NYPS TSPG SLVK H |
遺伝子ID: | 6258 |
Uniprot: | P48443 |
セルラーロケーション: | Nucleus |
計算された分子量: | 50kDa |
観察された分子量: | 61kDa |
同義語: | RXRG, NR2B3, RXRC |
バックグラウンド: | This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. |
UniProt Protein Function: | RXRG: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Belongs to the nuclear hormone receptor family. NR2 subfamily. |
UniProt Protein Details: | Protein type:DNA-binding; Nuclear receptor Chromosomal Location of Human Ortholog: 1q22-q23 Cellular Component: nucleoplasm Molecular Function:protein binding; zinc ion binding; retinoid-X receptor activity; steroid hormone receptor activity Biological Process: retinoic acid receptor signaling pathway; neuron differentiation; transcription initiation from RNA polymerase II promoter; skeletal muscle development; response to retinoic acid; regulation of myelination; heart development; steroid hormone mediated signaling; gene expression; transmembrane transport; protein homotetramerization; peripheral nervous system development |
NCBI Summary: | This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010] |
UniProt Code: | P48443 |
NCBI GenInfo Identifier: | 1350913 |
NCBI Gene ID: | 6258 |
NCBI Accession: | P48443.1 |
UniProt Secondary Accession: | P48443,Q6IBU7, A6NIP1, |
UniProt Related Accession: | P48443 |
Molecular Weight: | 50,871 Da |
NCBI Full Name: | Retinoic acid receptor RXR-gamma |
NCBI Synonym Full Names: | retinoid X receptor, gamma |
NCBI Official Symbol: | RXRG |
NCBI Official Synonym Symbols: | RXRC; NR2B3 |
NCBI Protein Information: | retinoic acid receptor RXR-gamma; nuclear receptor subfamily 2 group B member 3 |
UniProt Protein Name: | Retinoic acid receptor RXR-gamma |
UniProt Synonym Protein Names: | Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma |
UniProt Gene Name: | RXRG |
UniProt Entry Name: | RXRG_HUMAN |
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