Anti-RUFY3 Antibody (CAB12896)
- SKU:
- CAB12896
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-RUFY3 Antibody |
抗体コード: | CAB12896 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-65 of human RUFY3 (NP_055776.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse brain, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-65 of human RUFY3 (NP_055776.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSAL TPPT DMPT PTTD KITQ AAME TIYL CKFR VSMD GEWL CLRE LDDI SLTP DPEP THED PNYL M |
遺伝子ID: | 22902 |
Uniprot: | Q7L099 |
セルラーロケーション: | Cell projection, Cytoplasm, Endomembrane system, Perikaryon, filopodium, growth cone, invadopodium, lamellipodium |
計算された分子量: | 52kDa/55kDa/64kDa/70kDa |
観察された分子量: | 56kDa |
同義語: | RUFY3, RIPX, SINGAR1, ZFYVE30 |
バックグラウンド: | This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | RUFY3: Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell development/differentiation Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: axon; cytoplasm; cytosol; dendrite; filopodium; growth cone; lamellipodium; perikaryon Molecular Function:protein binding Biological Process: actin filament organization; negative regulation of axonogenesis; positive regulation of axon extension; positive regulation of cell migration |
NCBI Summary: | This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] |
UniProt Code: | Q7L099 |
NCBI GenInfo Identifier: | 74738521 |
NCBI Gene ID: | 22902 |
NCBI Accession: | Q7L099.1 |
UniProt Secondary Accession: | Q7L099,O94948, Q9UI00, B3KM25, B4DYW7, D9N163, |
UniProt Related Accession: | Q7L099 |
Molecular Weight: | 53kDa |
NCBI Full Name: | Protein RUFY3 |
NCBI Synonym Full Names: | RUN and FYVE domain containing 3 |
NCBI Official Symbol: | RUFY3 |
NCBI Official Synonym Symbols: | RIPX; SINGAR1; ZFYVE30 |
NCBI Protein Information: | protein RUFY3 |
UniProt Protein Name: | Protein RUFY3 |
UniProt Synonym Protein Names: | RUN and FYVE domain-containing protein 3 |
Protein Family: | Protein |
UniProt Gene Name: | RUFY3 |
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