Anti-RPA70 Antibody (CAB3367)
- SKU:
- CAB3367
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
抗体名: | Anti-RPA70 Antibody |
抗体コード: | CAB3367 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human RPA70 |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Rat |
ポジティブサンプル: | HeLa, U-251MG, Rat testis |
免疫原: | A synthesized peptide derived from human RPA70 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 6117 |
Uniprot: | P27694 |
セルラーロケーション: | |
計算された分子量: | 70kDa |
観察された分子量: | 70KDa |
同義語: | HSSB, MST075, REPA1, RF-A, RP-A, RPA70 |
バックグラウンド: |
UniProt Protein Function: | RPA1: Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing. Heterotrimer composed of RPA1, RPA2 and RPA3 (canonical replication protein A complex). Component of the alternative replication protein A complex (aRPA) composed of RPA1, RPA3 and RPA4. The DNA-binding activity may reside exclusively on the RPA1 subunit. Interacts with RIPK1 and XPA. Interacts with RPA4. Interacts with the polymerase alpha subunit POLA1/p180; this interaction stabilizes the replicative complex and reduces the misincorporation rate of DNA polymerase alpha by acting as a fidelity clamp. Interact with RAD51 and SENP6 to regulate DNA repair. Interacts with HELB; this interaction promotes HELB recruitement to chromatin following DNA damage. Belongs to the replication factor A protein 1 family. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: male germ cell nucleus; nucleoplasm; lateral element; PML body; DNA replication factor A complex; nucleus Molecular Function:protein binding; metal ion binding; damaged DNA binding; chromatin binding; single-stranded DNA binding Biological Process: meiosis; mismatch repair; in utero embryonic development; DNA strand elongation during DNA replication; DNA repair; double-strand break repair via homologous recombination; DNA recombination; telomere maintenance via semi-conservative replication; DNA recombinase assembly; homeostasis of number of cells within a tissue; base-excision repair; nucleotide-excision repair; double-strand break repair; transcription-coupled nucleotide-excision repair; positive regulation of cell proliferation; telomere maintenance via recombination; hemopoiesis; nucleotide-excision repair, DNA damage removal; nucleotide-excision repair, DNA gap filling; mitotic cell cycle; DNA replication; DNA-dependent DNA replication; telomere maintenance; G1/S transition of mitotic cell cycle |
UniProt Code: | P27694 |
NCBI GenInfo Identifier: | 1350579 |
NCBI Gene ID: | 6117 |
NCBI Accession: | P27694.2 |
UniProt Secondary Accession: | P27694,Q59ES9, A8K0Y9, |
UniProt Related Accession: | P27694 |
Molecular Weight: | 616 |
NCBI Full Name: | Replication protein A 70 kDa DNA-binding subunit |
NCBI Synonym Full Names: | replication protein A1, 70kDa |
NCBI Official Symbol: | RPA1 |
NCBI Official Synonym Symbols: | HSSB; RF-A; RP-A; REPA1; RPA70; MST075 |
NCBI Protein Information: | replication protein A 70 kDa DNA-binding subunit; MSTP075; RP-A p70; RF-A protein 1; replication factor A protein 1; single-stranded DNA-binding protein |
UniProt Protein Name: | Replication protein A 70 kDa DNA-binding subunit |
UniProt Synonym Protein Names: | Replication factor A protein 1; RF-A protein 1; Single-stranded DNA-binding proteinReplication protein A 70 kDa DNA-binding subunit, N-terminally processed |
Protein Family: | Replication factor |
UniProt Gene Name: | RPA1 |
UniProt Entry Name: | RFA1_HUMAN |