Anti-RIT1 Antibody (CAB15715)
- SKU:
- CAB15715
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-RIT1 Antibody |
抗体コード: | CAB15715 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RIT1 (NP_001243749.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse kidnay, Rat kdney |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RIT1 (NP_001243749.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SDLK QLRQ VTKE EGLA LARE FSCP FFET SAAY RYYI DDVF HALV REIR RKEK EAVL AMEK KSKP KNSV WKRL KSPF RKKK DSVT |
遺伝子ID: | 6016 |
Uniprot: | Q92963 |
セルラーロケーション: | Cell membrane |
計算された分子量: | 21kDa/25kDa/27kDa |
観察された分子量: | 30kDa |
同義語: | RIT1, NS8, RIBB, RIT, ROC1 |
バックグラウンド: | This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. |
UniProt Protein Function: | RIT1: a small G protein of the Ras family. Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and p38-alpha signaling pathways and in NGF- dependent neuronal differentiation. Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation. Interacts with afadin, the C-terminal domain of RalGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with c-Raf. BRAF and c-RAF association is dependent upon the GTP-bound state. Interacts with RGL3. Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members. |
UniProt Protein Details: | Protein type:G protein, monomeric, Ras; G protein; G protein, monomeric Chromosomal Location of Human Ortholog: 1q22 Molecular Function:calmodulin binding; protein binding Biological Process: Ras protein signal transduction; signal transduction Disease: Noonan Syndrome 8 |
NCBI Summary: | This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q92963 |
NCBI GenInfo Identifier: | 38258628 |
NCBI Gene ID: | 6016 |
NCBI Accession: | Q92963.1 |
UniProt Secondary Accession: | Q92963,O00646, O00720, Q5VY89, Q5VY90, B4DQE8, |
UniProt Related Accession: | Q92963 |
Molecular Weight: | 27,148 Da |
NCBI Full Name: | GTP-binding protein Rit1 |
NCBI Synonym Full Names: | Ras like without CAAX 1 |
NCBI Official Symbol: | RIT1 |
NCBI Official Synonym Symbols: | NS8; RIT; RIBB; ROC1 |
NCBI Protein Information: | GTP-binding protein Rit1 |
UniProt Protein Name: | GTP-binding protein Rit1 |
UniProt Synonym Protein Names: | Ras-like protein expressed in many tissues; Ras-like without CAAX protein 1 |
Protein Family: | GTP-binding protein |
UniProt Gene Name: | RIT1 |
UniProt Entry Name: | RIT1_HUMAN |
View AllClose