Anti-RIF1 Antibody (CAB15167)
- SKU:
- CAB15167
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
抗体名: | Anti-RIF1 Antibody |
抗体コード: | CAB15167 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 2173-2472 of human RIF1 (NP_060621.3). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | U-87MG, HeLa, 293T, LO2 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 2173-2472 of human RIF1 (NP_060621.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | PLAS PSTS ILKR GLKR SQED EISS PVNK VRRV SFAD PIYQ AGLA DDID RRCS IVRS HSSN SSPI GKSV KTSP TTQS KHNT TSAK GFLS PGSR SPKF KSSK KCLI SEMA KESI PCPT ESVY PPLV NCVA PVDI ILPQ ITSN MWAR GLGQ LIRA KNIK TIGD LSTL TASE IKTL PIRS PKVS NVKK ALRI YHEQ QVKT RGLE EIPV FDIS EKTV NGIE NKSL SPDE ERLV SDII DPVA LEIP LSKN LLAQ ISAL ALQL DSED LHNY SGSQ LFEM HEKL SCMA NSVI KNLQ SRWR SPSH ENSI |
遺伝子ID: | 55183 |
Uniprot: | Q5UIP0 |
セルラーロケーション: | Chromosome, Cytoplasm, Nucleus, cytoskeleton, spindle, telomere |
計算された分子量: | 271kDa/274kDa |
観察された分子量: | 350kDa |
同義語: | RIF1 |
バックグラウンド: | This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants. |
UniProt Protein Function: | RIF1: Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S- phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 2q23.3 Cellular Component: condensed chromosome; nucleoplasm; nucleus; plasma membrane; spindle midzone Biological Process: double-strand break repair via nonhomologous end joining; telomere maintenance in response to DNA damage |
NCBI Summary: | This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] |
UniProt Code: | Q5UIP0 |
NCBI GenInfo Identifier: | 56676335 |
NCBI Gene ID: | 55183 |
NCBI Accession: | NP_060621.3 |
UniProt Secondary Accession: | Q5UIP0,Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772 Q9H830, Q9H9B9, Q9NVP5, A6NC27, C9JBR1, |
UniProt Related Accession: | Q5UIP0 |
Molecular Weight: | 271,689 Da |
NCBI Full Name: | telomere-associated protein RIF1 isoform 1 |
NCBI Synonym Full Names: | replication timing regulatory factor 1 |
NCBI Official Symbol: | RIF1 |
NCBI Protein Information: | telomere-associated protein RIF1 |
UniProt Protein Name: | Telomere-associated protein RIF1 |
UniProt Synonym Protein Names: | Rap1-interacting factor 1 homolog |
Protein Family: | Telomere-associated protein |
UniProt Gene Name: | RIF1 |
UniProt Entry Name: | RIF1_HUMAN |
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