Anti-RBM14 Antibody (CAB4418)

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SKU:
CAB4418
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
RBM14
Synonyms:
COAA
Synonyms:
PSP2
Synonyms:
SIP
Synonyms:
SYTIP1
Synonyms:
TMEM137
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Description

I抗体名:RBM14 Rabbit pAb
抗体コード:CAB4418
サイズ:20uL, 50uL, 100uL
同義語:RBM14, COAA, PSP2, SIP, SYTIP1, TMEM137
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-99 of human RBM14 (NP_006319.1).
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa, 293T, Jurkat, Mouse thymus, Rat testis
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-99 of human RBM14 (NP_006319.1).
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MKIF VGNV DGAD TTPE ELAA LFAP YGTV MSCA VMKQ FAFV HMRE NAGA LRAI EALH GHEL RPGR ALVV EMSR PRPL NTWK IFVG NVSA ACTS QELR SLF
遺伝子ID:10432
Uniprot:Q96PK6
セルラーロケーション:Nucleus, nucleolus
計算された分子量:12kDa/13kDa/17kDa/37kDa/69kDa
観察された分子量:75KDa
UniProt Protein Function:RBM14: an RNA binding protein and transcriptional regulator. Expressed in all tissues tested, including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes. Two alternatively spliced isoforms have been observed. Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1.
UniProt Protein Details:

Protein type:Nucleolus; RNA-binding; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: nucleoplasm; transcription factor complex; nucleolus; Srb-mediator complex; ribonucleoprotein complex

Molecular Function:protein binding, bridging; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; RNA binding; nucleotide binding

Biological Process: transcription from RNA polymerase II promoter; estrogen receptor signaling pathway; glucocorticoid receptor signaling pathway; response to hormone stimulus; histone deacetylation; positive regulation of transcription from RNA polymerase II promoter; DNA repair; DNA replication; DNA recombination

NCBI Summary:This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:Q96PK6
NCBI GenInfo Identifier:73913750
NCBI Gene ID:10432
NCBI Accession:Q96PK6.2
UniProt Secondary Accession:Q96PK6,Q8C2Q3,
UniProt Related Accession:Q96PK6
Molecular Weight:669
NCBI Full Name:RNA-binding protein 14
NCBI Synonym Full Names:RNA binding motif protein 14
NCBI Official Symbol:RBM14  
NCBI Official Synonym Symbols:SIP; COAA; PSP2; SYTIP1; TMEM137  
NCBI Protein Information:RNA-binding protein 14; paraspeckle protein 2; SYT-interacting protein; transmembrane protein 137; synaptotagmin-interacting protein; RRM-containing coactivator activator/modulator
UniProt Protein Name:RNA-binding protein 14
UniProt Synonym Protein Names:Paraspeckle protein 2; PSP2; RNA-binding motif protein 14; RRM-containing coactivator activator/modulator; Synaptotagmin-interacting protein; SYT-interacting protein
Protein Family:RNA-binding protein
UniProt Gene Name:RBM14  
UniProt Entry Name:RBM14_HUMAN
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