Anti-PURA Antibody (CAB9296)
- SKU:
- CAB9296
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-PURA Antibody |
抗体コード: | CAB9296 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 203-322 of human PURA (NP_005850.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | MCF7, A-549, HeLa, HepG2, Jurkat |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 203-322 of human PURA (NP_005850.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | AKLI DDYG VEEE PAEL PEGT SLTV DNKR FFFD VGSN KYGV FMRV SEVK PTYR NSIT VPYK VWAK FGHT FCKY SEEM KKIQ EKQR EKRA ACEQ LHQQ QQQQ QEET AAAT LLLQ GEEE GEED |
遺伝子ID: | 5813 |
Uniprot: | Q00577 |
セルラーロケーション: | Nucleus |
計算された分子量: | 34kDa |
観察された分子量: | 36kDa |
同義語: | PURA, MRD31, PUR-ALPHA, PUR1, PURALPHA |
バックグラウンド: | This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. |
UniProt Protein Function: | PURA: This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination. Belongs to the PUR DNA-binding protein family. |
UniProt Protein Details: | Protein type:DNA-binding; RNA-binding Chromosomal Location of Human Ortholog: 5q31 Cellular Component: DNA replication factor A complex; nuclear chromosome, telomeric region; nucleus Molecular Function:double-stranded telomeric DNA binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; single-stranded DNA binding; transcription factor binding Biological Process: DNA replication initiation; DNA unwinding during replication Disease: Mental Retardation, Autosomal Dominant 31 |
NCBI Summary: | This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q00577 |
NCBI GenInfo Identifier: | 1346918 |
NCBI Gene ID: | 5813 |
NCBI Accession: | Q00577.2 |
UniProt Related Accession: | Q00577 |
Molecular Weight: | 34,911 Da |
NCBI Full Name: | Transcriptional activator protein Pur-alpha |
NCBI Synonym Full Names: | purine rich element binding protein A |
NCBI Official Symbol: | PURA |
NCBI Official Synonym Symbols: | PUR1; MRD31; PURALPHA; PUR-ALPHA |
NCBI Protein Information: | transcriptional activator protein Pur-alpha |
UniProt Protein Name: | Transcriptional activator protein Pur-alpha |
UniProt Synonym Protein Names: | Purine-rich single-stranded DNA-binding protein alpha |
Protein Family: | Puratrophin |
UniProt Gene Name: | PURA |
UniProt Entry Name: | PURA_HUMAN |
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