Anti-PTPRN2 Antibody (CAB14774)
- SKU:
- CAB14774
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-PTPRN2 Antibody |
抗体コード: | CAB14774 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-242 of human PTPRN2 (NP_570858.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SH-SY5Y, SGC-7901, Mouse pancreas, Rat pancreas |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-242 of human PTPRN2 (NP_570858.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | AAPS SVPR GRQL PGRL GCLL EEGL CGAS EACV NDGV FGRC QKVP AMDF YRYE VSPV ALQR LRVA LQKL SGTG FTWQ DDYT QYVM DQEL ADLP KTYL RRPE ASSP ARPS KHSV GSER RYSR EGGA ALAN ALRR HLPF LEAL SQAP ASDV LART HTAQ DRPP AEGD DRFS ESIL TYVA HTSA LTYP PGSR TQLR EDLL PRTL GQLQ PDEL SPKV DSGV DRHH L |
遺伝子ID: | 5799 |
Uniprot: | Q92932 |
セルラーロケーション: | Cytoplasmic vesicle, Single-pass type I membrane protein, secretory vesicle, secretory vesicle membrane, synaptic vesicle membrane |
計算された分子量: | 108kDa/109kDa/111kDa/114kDa |
観察された分子量: | 111kDa |
同義語: | PTPRN2, IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2 |
バックグラウンド: | This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4, 5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | PTPRN2: Implicated in development of nervous system and pancreatic endocrine cells. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 3.1.3.48; Membrane protein, integral; Receptor protein phosphatase, tyrosine Chromosomal Location of Human Ortholog: 7q36 Cellular Component: integral to plasma membrane; receptor complex; secretory granule membrane; synaptic vesicle membrane Molecular Function:transmembrane receptor protein tyrosine phosphatase activity Biological Process: neurotransmitter secretion; protein amino acid dephosphorylation |
NCBI Summary: | This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
UniProt Code: | Q92932 |
NCBI GenInfo Identifier: | 116242738 |
NCBI Gene ID: | 5799 |
NCBI Accession: | Q92932.2 |
UniProt Secondary Accession: | Q92932,Q8N4I5, Q92662, Q9Y4F8, Q9Y4I6, E9PC57, |
UniProt Related Accession: | Q92932 |
Molecular Weight: | 109,622 Da |
NCBI Full Name: | Receptor-type tyrosine-protein phosphatase N2 |
NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type N2 |
NCBI Official Symbol: | PTPRN2 |
NCBI Official Synonym Symbols: | IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2 |
NCBI Protein Information: | receptor-type tyrosine-protein phosphatase N2 |
UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase N2 |
UniProt Synonym Protein Names: | Islet cell autoantigen-related protein |
Protein Family: | Receptor-type tyrosine-protein phosphatase |
UniProt Gene Name: | PTPRN2 |
UniProt Entry Name: | PTPR2_HUMAN |
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