Anti-PSMD10 Antibody (CAB1949)
- SKU:
- CAB1949
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
抗体名: | Anti-PSMD10 Antibody |
抗体コード: | CAB1949 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-226 of human PSMD10 (NP_002805.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SW620 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-226 of human PSMD10 (NP_002805.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MEGC VSNL MVCN LAYS GKLE ELKE SILA DKSL ATRT DQDS RTAL HWAC SAGH TEIV EFLL QLGV PVND KDDA GWSP LHIA ASAG RDEI VKAL LGKG AQVN AVNQ NGCT PLHY AASK NRHE IAVM LLEG GANP DAKD HYEA TAMH RAAA KGNL KMIH ILLY YKAS TNIQ DTEG NTPL HLAC DEER VEEA KLLV SQGA SIYI ENKE EKTP LQVA KGGL GLIL KRMV EG |
遺伝子ID: | 5716 |
Uniprot: | O75832 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 16kDa/24kDa |
観察された分子量: | 24kDa |
同義語: | PSMD10, dJ889N15.2, p28, p28(GANK) |
バックグラウンド: | This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20. |
UniProt Protein Function: | PSMD10: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Proteasome complex; Protease Chromosomal Location of Human Ortholog: Xq22.3 Cellular Component: proteasome complex; nucleoplasm; intermediate filament cytoskeleton; proteasome regulatory particle; cytoplasm; nucleus; cytosol Molecular Function:protein binding; transcription factor binding Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of cyclin-dependent protein kinase activity; protein polyubiquitination; viral reproduction; apoptosis; negative regulation of transcription from RNA polymerase II promoter; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; antigen processing and presentation of peptide antigen via MHC class I; cytoplasmic sequestering of NF-kappaB; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; negative regulation of MAPKKK cascade; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of cell growth; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis |
NCBI Summary: | This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011] |
UniProt Code: | O75832 |
NCBI GenInfo Identifier: | 20532206 |
NCBI Gene ID: | 5716 |
NCBI Accession: | O75832.1 |
UniProt Related Accession: | O75832 |
Molecular Weight: | 16kDa; 24kDa |
NCBI Full Name: | 26S proteasome non-ATPase regulatory subunit 10 |
NCBI Synonym Full Names: | proteasome 26S subunit, non-ATPase 10 |
NCBI Official Symbol: | PSMD10 |
NCBI Official Synonym Symbols: | p28; p28(GANK); dJ889N15.2 |
NCBI Protein Information: | 26S proteasome non-ATPase regulatory subunit 10 |
UniProt Protein Name: | 26S proteasome non-ATPase regulatory subunit 10 |
UniProt Synonym Protein Names: | 26S proteasome regulatory subunit p28; Gankyrin; p28(GANK) |
Protein Family: | 26S proteasome non-ATPase regulatory |
UniProt Gene Name: | PSMD10 |
UniProt Entry Name: | PSD10_HUMAN |