Anti-PRR5 Antibody (CAB15170)
- SKU:
- CAB15170
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
抗体名: | Anti-PRR5 Antibody |
抗体コード: | CAB15170 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 109-388 of human PRR5 (NP_851850.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Mouse kidney, Mouse lung |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 109-388 of human PRR5 (NP_851850.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | QKLL DSLA ETWD FFFS DVLP MLQA IFYP VQGK EPSV RQLA LLHF RNAI TLSV KLED ALAR AHAR VPPA IVQM LLVL QGVH ESRG VTED YLRL ETLV QKVV SPYL GTYG LHSS EGPF THSC ILEK RLLR RSRS GDVL AKNP VVRS KSYN TPLL NPVQ EHEA EGAA AGGT SIRR HSVS EMTS CPEP QGFS DPPG QGPT GTFR SSPA PHSG PCPS RLYP TTQP PEQG LDPT RSSL PRSS PENL VDQI LESV DSDS EGIF IDFG RGRG SGMS DLEG SGGR QSVV |
遺伝子ID: | 55615 |
Uniprot: | P85299 |
セルラーロケーション: | |
計算された分子量: | 31kDa/32kDa/41kDa/42kDa/45kDa |
観察された分子量: | 53kDa |
同義語: | PRR5, FLJ20185k, PP610, PROTOR-1, PROTOR1 |
バックグラウンド: | This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. |
UniProt Protein Function: | PROTOR1: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. Belongs to the PROTOR family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 22q13 Cellular Component: TORC2 complex Biological Process: positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; cell cycle |
NCBI Summary: | This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010] |
UniProt Code: | P85299 |
NCBI GenInfo Identifier: | 31317218 |
NCBI Gene ID: | 55615 |
NCBI Accession: | NP_851850 |
UniProt Secondary Accession: | P85299,O75983, O95695, Q5BIW2, Q5EAJ8, Q5EAJ9, Q5XKJ6 Q96RW1, Q96RW2, B1AHF6, B1AHG5, B3KP73, |
UniProt Related Accession: | P85299 |
Molecular Weight: | 45,172 Da |
NCBI Full Name: | proline-rich protein 5 isoform 1 |
NCBI Synonym Full Names: | proline rich 5 (renal) |
NCBI Official Symbol: | PRR5 |
NCBI Official Synonym Symbols: | PP610; PROTOR1; PROTOR-1; FLJ20185k |
NCBI Protein Information: | proline-rich protein 5; protein observed with Rictor-1; Rho GTPase activating protein 8 |
UniProt Protein Name: | Proline-rich protein 5 |
UniProt Synonym Protein Names: | Protein observed with Rictor-1; Protor-1 |
Protein Family: | Proline-rich protein |
UniProt Gene Name: | PRR5 |
UniProt Entry Name: | PRR5_HUMAN |
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