Anti-PRAME Antibody (CAB14507)
- SKU:
- CAB14507
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
抗体名: | Anti-PRAME Antibody |
抗体コード: | CAB14507 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PRAME (NP_006106.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U2OS, U-251MG, Mouse liver, Mouse lung, Rat lung |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PRAME (NP_006106.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MERR RLWG SIQS RYIS MSVW TSPR RLVE LAGQ SLLK DEAL AIAA LELL PREL FPPL FMAA FDGR HSQT LKAM VQAW PFTC LPLG VLMK GQHL HLET FKAV LDGL DVLL AQEV RPRR WKLQ VLDL RKNS HQDF WTVW SGNR ASLY SFPE PEAA QPMT KKRK VDGL STEA EQPF IPVE VLVD LFLK EGAC DELF SYLI EKVK |
遺伝子ID: | 23532 |
Uniprot: | P78395 |
セルラーロケーション: | Cell membrane, Nucleus |
計算された分子量: | 57kDa |
観察された分子量: | 58kDa |
同義語: | PRAME, CT130, MAPE, OIP-4, OIP4 |
バックグラウンド: | This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | PRAME: Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Belongs to the PRAME family. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Cancer Testis Antigen (CTA); Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 22q11.22 Molecular Function:protein binding; retinoic acid receptor binding Biological Process: negative regulation of apoptosis; negative regulation of cell differentiation; negative regulation of retinoic acid receptor signaling pathway; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation |
NCBI Summary: | This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
UniProt Code: | P78395 |
NCBI GenInfo Identifier: | 6685631 |
NCBI Gene ID: | 23532 |
NCBI Accession: | P78395.1 |
UniProt Secondary Accession: | P78395,O43481, Q8IXN8, B2R6Y7, |
UniProt Related Accession: | P78395 |
Molecular Weight: | 57,890 Da |
NCBI Full Name: | Melanoma antigen preferentially expressed in tumors |
NCBI Synonym Full Names: | preferentially expressed antigen in melanoma |
NCBI Official Symbol: | PRAME |
NCBI Official Synonym Symbols: | MAPE; OIP4; CT130; OIP-4 |
NCBI Protein Information: | melanoma antigen preferentially expressed in tumors |
UniProt Protein Name: | Melanoma antigen preferentially expressed in tumors |
UniProt Synonym Protein Names: | Opa-interacting protein 4; OIP-4; Preferentially expressed antigen of melanoma |
Protein Family: | Melanoma antigen |
UniProt Gene Name: | PRAME |
UniProt Entry Name: | PRAME_HUMAN |
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