Anti-PPP1R3A Antibody (CAB10171)
- SKU:
- CAB10171
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-PPP1R3A Antibody |
抗体コード: | CAB10171 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 900-1080 of human PPP1R3A (NP_002702.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse |
ポジティブサンプル: | Mouse liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 900-1080 of human PPP1R3A (NP_002702.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SAFN SDTN RAPQ NSSP FSKH HTEI SVST NEQA IAVE NAVT TMAS QPIS TKSE NICN STRE IQGI EKHP YPES KPEE VSRS SGIV TSGS RKER CIGQ IFQT EEYS VEKS LGPM ILIN KPLE NMEE ARHE NEGL VSSG QSLY TSGE KESD SSAS TSLP VEES QAQG NESL FSKY TNSK IPYF L |
遺伝子ID: | 5506 |
Uniprot: | Q16821 |
セルラーロケーション: | Membrane, Single-pass membrane protein |
計算された分子量: | 8kDa/125kDa |
観察された分子量: | 150kDa |
同義語: | PPP1R3A, GM, PP1G, PPP1R3 |
バックグラウンド: | The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase. |
UniProt Protein Function: | PPP1R3A: Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase. Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen. Skeletal muscle and heart. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Protein phosphatase, regulatory subunit Chromosomal Location of Human Ortholog: 7q31.1 Disease: Lipodystrophy, Familial Partial, Type 3 |
NCBI Summary: | The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q16821 |
NCBI GenInfo Identifier: | 298286906 |
NCBI Gene ID: | 5506 |
NCBI Accession: | Q16821.3 |
UniProt Secondary Accession: | Q16821,O43476, Q75LN8, Q7KYM8, Q86UI6, A0AVQ2, A4D0T6 |
UniProt Related Accession: | Q16821 |
Molecular Weight: | 8,187 Da |
NCBI Full Name: | Protein phosphatase 1 regulatory subunit 3A |
NCBI Synonym Full Names: | protein phosphatase 1 regulatory subunit 3A |
NCBI Official Symbol: | PPP1R3A |
NCBI Official Synonym Symbols: | GM; PP1G; PPP1R3 |
NCBI Protein Information: | protein phosphatase 1 regulatory subunit 3A |
UniProt Protein Name: | Protein phosphatase 1 regulatory subunit 3A |
UniProt Synonym Protein Names: | Protein phosphatase 1 glycogen-associated regulatory subunit; Protein phosphatase type-1 glycogen targeting subunit; RG1 |
Protein Family: | Protein phosphatase 1 regulatory |
UniProt Gene Name: | PPP1R3A |
UniProt Entry Name: | PPR3A_HUMAN |
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