Anti-PPME1 Antibody (CAB13094)
- SKU:
- CAB13094
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-PPME1 Antibody |
抗体コード: | CAB13094 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human PPME1 (NP_057231.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, A-549, Mouse testis, Rat testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human PPME1 (NP_057231.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSAL EKSM HLGR LPSR PPLP GSGG SQSG AKMR MGPG RKRD FSPV PWSQ YFES MEDV EVEN ETGK DTFR VYKS GSEG PVLL LLHG GGHS ALSW AVFT AAII SRVQ CRIV ALDL RSHG ETKV KNPE DLSA ETMA KDVG NVVE AMYG DLPP PIML IGHS MGGA |
遺伝子ID: | 51400 |
Uniprot: | Q9Y570 |
セルラーロケーション: | |
計算された分子量: | 18kDa/22kDa/42kDa/43kDa |
観察された分子量: | 42kDa |
同義語: | PPME1, PME-1 |
バックグラウンド: | This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | PPME1: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. Belongs to the AB hydrolase superfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Hydrolase; Motility/polarity/chemotaxis; EC 3.1.1.89; Protein phosphatase, regulatory subunit Chromosomal Location of Human Ortholog: 11q13.4 Molecular Function:protein C-terminal methylesterase activity; protein phosphatase 2A binding; protein phosphatase binding; protein phosphatase inhibitor activity; protein phosphatase type 2A regulator activity Biological Process: protein amino acid demethylation |
NCBI Summary: | This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] |
UniProt Code: | Q9Y570 |
NCBI GenInfo Identifier: | 47606055 |
NCBI Gene ID: | 51400 |
NCBI Accession: | Q9Y570.3 |
UniProt Secondary Accession: | Q9Y570,Q8WYG8, Q9NVT5, Q9UI18, B3KMU6, B5MEE7, J3QT22 |
UniProt Related Accession: | Q9Y570 |
Molecular Weight: | 43,870 Da |
NCBI Full Name: | Protein phosphatase methylesterase 1 |
NCBI Synonym Full Names: | protein phosphatase methylesterase 1 |
NCBI Official Symbol: | PPME1 |
NCBI Official Synonym Symbols: | PME-1 |
NCBI Protein Information: | protein phosphatase methylesterase 1 |
UniProt Protein Name: | Protein phosphatase methylesterase 1 |
Protein Family: | Pectinesterase |
UniProt Gene Name: | PPME1 |
UniProt Entry Name: | PPME1_HUMAN |
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