Anti-POFUT1 Antibody (CAB8338)
- SKU:
- CAB8338
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-POFUT1 Antibody |
抗体コード: | CAB8338 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-194 of human POFUT1 (NP_758436.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HepG2, HL-60, Mouse heart, Mouse liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-194 of human POFUT1 (NP_758436.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SWDP AGYL LYCP CMGR FGNQ ADHF LGSL AFAK LLNR TLAV PPWI EYQH HKPP FTNL HVSY QKYF KLEP LQAY HRVI SLED FMEK LAPT HWPP EKRV AYCF EVAA QRSP DKKT CPMK EGNP FGPF WDQF HVSF NKSE LFTG ISFS ASYR EQWS QRRE NHSC VTLL FPR |
遺伝子ID: | 23509 |
Uniprot: | Q9H488 |
セルラーロケーション: | Endoplasmic reticulum |
計算された分子量: | 22kDa/43kDa |
観察された分子量: | 44kDa |
同義語: | POFUT1, DDD2, FUT12, O-FUT, O-Fuc-T, O-FucT-1, OFUCT1 |
バックグラウンド: | This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |
UniProt Protein Function: | POFUT1: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in EGF domains. Plays a crucial role in Notch signaling. Belongs to the glycosyltransferase 68 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transferase; EC 2.4.1.221 Chromosomal Location of Human Ortholog: 20q11 Cellular Component: endoplasmic reticulum; membrane Molecular Function:fucosyltransferase activity; peptide-O-fucosyltransferase activity Biological Process: O-glycan processing; protein amino acid O-linked glycosylation Disease: Dowling-degos Disease 2 |
NCBI Summary: | This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9H488 |
NCBI GenInfo Identifier: | 23396787 |
NCBI Gene ID: | 23509 |
NCBI Accession: | Q9H488.1 |
UniProt Secondary Accession: | Q9H488,Q14685, Q5W185, Q9BW76, A8K4R8, E1P5M4, |
UniProt Related Accession: | Q9H488 |
Molecular Weight: | 22,338 Da |
NCBI Full Name: | GDP-fucose protein O-fucosyltransferase 1 |
NCBI Synonym Full Names: | protein O-fucosyltransferase 1 |
NCBI Official Symbol: | POFUT1 |
NCBI Official Synonym Symbols: | DDD2; FUT12; O-FUT; OFUCT1; O-Fuc-T; O-FucT-1 |
NCBI Protein Information: | GDP-fucose protein O-fucosyltransferase 1 |
UniProt Protein Name: | GDP-fucose protein O-fucosyltransferase 1 |
UniProt Synonym Protein Names: | Peptide-O-fucosyltransferase 1; O-FucT-1 |
UniProt Gene Name: | POFUT1 |
UniProt Entry Name: | OFUT1_HUMAN |
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