Anti-PNPLA3 Antibody (CAB6694)
- SKU:
- CAB6694
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-PNPLA3 Antibody |
抗体コード: | CAB6694 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 377-481 of human PNPLA3 (NP_079501.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SKOV3, Mouse lung, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 377-481 of human PNPLA3 (NP_079501.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | PDMP DDVL WLQW VTSQ VFTR VLMC LLPA SRSQ MPVS SQQA SPCT PEQD WPCW TPCS PKGC PAET KAEA TPRS ILRS SLNF FLGN KVPA GAEG LSTF PSFS LEKS L |
遺伝子ID: | 80339 |
Uniprot: | Q9NST1 |
セルラーロケーション: | Membrane, Single-pass type II membrane protein |
計算された分子量: | 52kDa |
観察された分子量: | 53kDa |
同義語: | PNPLA3, ADPN, C22orf20 |
バックグラウンド: | The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. |
UniProt Protein Function: | PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Phospholipase; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation; EC 3.1.1.3; Lipid Metabolism - glycerolipid; Amino Acid Metabolism - phenylalanine; Transferase; Amino Acid Metabolism - tyrosine; Membrane protein, integral Chromosomal Location of Human Ortholog: 22q13.31 Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane Molecular Function:acylglycerol O-acyltransferase activity; diolein transacylation activity; lipoprotein lipase activity; mono-olein transacylation activity; phospholipase A2 activity; triacylglycerol lipase activity Biological Process: triacylglycerol biosynthetic process; triacylglycerol catabolic process |
NCBI Summary: | The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NST1 |
NCBI GenInfo Identifier: | 32469599 |
NCBI Gene ID: | 80339 |
NCBI Accession: | Q9NST1.2 |
UniProt Secondary Accession: | Q9NST1,Q6P1A1, Q96CB4, B0QYI0, B2RCL3, B3KW00, |
UniProt Related Accession: | Q9NST1 |
Molecular Weight: | |
NCBI Full Name: | Patatin-like phospholipase domain-containing protein 3 |
NCBI Synonym Full Names: | patatin like phospholipase domain containing 3 |
NCBI Official Symbol: | PNPLA3 |
NCBI Official Synonym Symbols: | ADPN; C22orf20; iPLA(2)epsilon |
NCBI Protein Information: | patatin-like phospholipase domain-containing protein 3 |
UniProt Protein Name: | Patatin-like phospholipase domain-containing protein 3 |
UniProt Synonym Protein Names: | Acylglycerol O-acyltransferase (EC:2.3.1.-); Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon |
Protein Family: | Patatin-like phospholipase domain-containing protein |
UniProt Gene Name: | PNPLA3 |
UniProt Entry Name: | PLPL3_HUMAN |
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