Anti-PNMT Antibody (CAB5553)
- SKU:
- CAB5553
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-PNMT Antibody |
抗体コード: | CAB5553 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-282 of human PNMT (NP_002677.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | K-562, Mouse liver, Mouse heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-282 of human PNMT (NP_002677.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSGA DRSP NAGA APDS APGQ AAVA SAYQ RFEP RAYL RNNY APPR GDLC NPNG VGPW KLRC LAQT FATG EVSG RTLI DIGS GPTV YQLL SACS HFED ITMT DFLE VNRQ ELGR WLQE EPGA FNWS MYSQ HACL IEGK GECW QDKE RQLR ARVK RVLP IDVH QPQP LGAG SPAP LPAD ALVS AFCL EAVS PDLA SFQR ALDH ITTL LRPG GHLL LIGA LEES WYLA GEAR LTVV PVSE EEVR EALV RSGY KVRD LRTY IMPA HLQT GVDD VKGV FFAW AQKV GL |
遺伝子ID: | 5409 |
Uniprot: | P11086 |
セルラーロケーション: | |
計算された分子量: | 30kDa |
観察された分子量: | 31-34kDa |
同義語: | PNMT, PENT, PNMTase |
バックグラウンド: | The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. |
UniProt Protein Function: | PNMT: Converts noradrenaline to adrenaline. Belongs to the NNMT/PNMT/TEMT family. |
UniProt Protein Details: | Protein type:Methyltransferase; EC 2.1.1.28; Amino Acid Metabolism - tyrosine Chromosomal Location of Human Ortholog: 17q12 Cellular Component: cytosol Molecular Function:phenylethanolamine N-methyltransferase activity Biological Process: methylation; catecholamine biosynthetic process; epinephrine biosynthetic process Disease: Hypertension, Essential |
NCBI Summary: | The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012] |
UniProt Code: | P11086 |
NCBI GenInfo Identifier: | 130375 |
NCBI Gene ID: | 5409 |
NCBI Accession: | P11086.1 |
UniProt Related Accession: | P11086 |
Molecular Weight: | 282 |
NCBI Full Name: | Phenylethanolamine N-methyltransferase |
NCBI Synonym Full Names: | phenylethanolamine N-methyltransferase |
NCBI Official Symbol: | PNMT |
NCBI Official Synonym Symbols: | PENT; PNMTase |
NCBI Protein Information: | phenylethanolamine N-methyltransferase; phenylethanolamine N-methylase; noradrenaline N-methyltransferase |
UniProt Protein Name: | Phenylethanolamine N-methyltransferase |
UniProt Synonym Protein Names: | Noradrenaline N-methyltransferase |
Protein Family: | Phenylethanolamine N-methyltransferase |
UniProt Gene Name: | PNMT |
UniProt Entry Name: | PNMT_HUMAN |
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