Anti-PMVK Antibody (CAB13866)

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SKU:
CAB13866
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
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Description

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抗体名:Anti-PMVK Antibody
抗体コード:CAB13866
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-192 of human PMVK (NP_006547.1).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human
ポジティブサンプル:293T, LO2, A-431, HeLa
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-192 of human PMVK (NP_006547.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MAPL GGAP RLVL LFSG KRKS GKDF VTEA LQSR LGAD VCAV LRLS GPLK EQYA QEHG LNFQ RLLD TSTY KEAF RKDM IRWG EEKR QADP GFFC RKIV EGIS QPIW LVSD TRRV SDIQ WFRE AYGA VTQT VRVV ALEQ SRQQ RGWV FTPG VDDA ESEC GLDN FGDF DWVI ENHG VEQR LEEQ LENL IEFI RSRL
遺伝子ID:10654
Uniprot:Q15126
セルラーロケーション:Peroxisome
計算された分子量:21kDa
観察された分子量:22kDa
同義語:PMVK, HUMPMKI, PMK, PMKA, PMKASE, POROK1
バックグラウンド:This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:PMVK: Induced by sterol. Monomer.
UniProt Protein Details:

Protein type:Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.7.4.2; Kinase, other

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: membrane; peroxisome; cytosol

Molecular Function:phosphomevalonate kinase activity; ATP binding

Biological Process: isopentenyl diphosphate biosynthetic process, mevalonate pathway; sterol biosynthetic process; phosphorylation; cholesterol biosynthetic process

NCBI Summary:This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011]
UniProt Code:Q15126
NCBI GenInfo Identifier:3024422
NCBI Gene ID:10654
NCBI Accession:Q15126.3
UniProt Secondary Accession:Q15126,Q5TZW9,
UniProt Related Accession:Q15126
Molecular Weight:21,995 Da
NCBI Full Name:Phosphomevalonate kinase
NCBI Synonym Full Names:phosphomevalonate kinase
NCBI Official Symbol:PMVK  
NCBI Official Synonym Symbols:PMK; PMKA; PMKASE; HUMPMKI  
NCBI Protein Information:phosphomevalonate kinase; hPMK
UniProt Protein Name:Phosphomevalonate kinase
UniProt Gene Name:PMVK  
UniProt Entry Name:PMVK_HUMAN
Anti-PMVK Antibody (CAB13866)Western blot analysis of extracts of various cell lines, using PMVK antibody (CAB13866) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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