Anti-PMCH Antibody (CAB6692)
- SKU:
- CAB6692
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-PMCH Antibody |
抗体コード: | CAB6692 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-165 of human PMCH (NP_002665.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HT-29, MCF7, Mouse liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-165 of human PMCH (NP_002665.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ILLS ASKS IRNL DDDM VFNT FRLG KGFQ KEDT AEKS VIAP SLEQ YKND ESSF MNEE ENKV SKNT GSKH NFLN HGLP LNLA IKPY LALK GSVA FPAE NGVQ NTES TQEK REIG DEEN SAKF PIGR RDFD MLRC MLGR VYRP CWQV |
遺伝子ID: | 5367 |
Uniprot: | P20382 |
セルラーロケーション: | Secreted |
計算された分子量: | 18kDa |
観察された分子量: | 19kDa |
同義語: | PMCH, MCH, ppMCH, pro-MCH |
バックグラウンド: | This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5. |
UniProt Protein Function: | PMCH: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation. Belongs to the melanin-concentrating hormone family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 12q23-q24 |
NCBI Summary: | The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and later from rat hypothalamus. In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH) (summary by Nahon et al., 1992 [PubMed 1572663]).[supplied by OMIM, Jan 2011] |
UniProt Code: | P20382 |
NCBI GenInfo Identifier: | 229462960 |
NCBI Gene ID: | 5367 |
NCBI Accession: | P20382.3 |
UniProt Secondary Accession: | P20382,Q16044, Q8WVG0, |
UniProt Related Accession: | P20382 |
Molecular Weight: | 165 |
NCBI Full Name: | Pro-MCH |
NCBI Synonym Full Names: | pro-melanin-concentrating hormone |
NCBI Official Symbol: | PMCH |
NCBI Official Synonym Symbols: | MCH |
NCBI Protein Information: | pro-MCH |
UniProt Protein Name: | Pro-MCH |
Protein Family: | Pro-MCH |
UniProt Gene Name: | PMCH |
UniProt Entry Name: | MCH_HUMAN |
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