Anti-PLP1 Antibody (CAB20009)
- SKU:
- CAB20009
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Neuroscience
Frequently bought together:
Description
| 抗体名: | Anti-PLP1 Antibody |
| 抗体コード: | CAB20009 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 145-210 of human PLP1 (NP_955772.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Mouse heart, Mouse kidney, Rat brain, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 145-210 of human PLP1 (NP_955772.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TWTT CQSI AFPS KTSA SIGS LCAD ARMY GVLP WNAF PGKV CGSN LLSI CKTA EFQM TFHL FIAA FV |
| 遺伝子ID: | 5354 |
| Uniprot: | P60201 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein, Myelin membrane |
| 計算された分子量: | 26kDa/30kDa |
| 観察された分子量: | 20-25kDa |
 | Western blot - PLP1 Rabbit pAb (CAB20009) |
| 同義語: | PLP1, GPM6C, HLD1, MMPL, PLP, PLP/DM20, PMD, SPG2 |
| バックグラウンド: | This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. |
| UniProt Protein Function: | PLP1: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. Defects in PLP1 are the cause of leukodystrophy hypomyelinating type 1 (HLD1); also known as Pelizaeus-Merzbacher disease. HLD1 is an X-linked recessive dysmyelinating disorder of the central nervous system in which myelin is not formed properly. It is characterized clinically by nystagmus, spastic quadriplegia, ataxia, and developmental delay. Defects in PLP1 are the cause of spastic paraplegia X- linked type 2 (SPG2). SPG2 is characterized by spastic gait and hyperreflexia. In some patients, complicating features include nystagmus, dysarthria, sensory disturbance, mental retardation, optic atrophy. Belongs to the myelin proteolipid protein family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: Xq22.2 Cellular Component: integral component of membrane; myelin sheath; plasma membrane Molecular Function:protein binding; structural constituent of myelin sheath; structural molecule activity Biological Process: astrocyte development; axon ensheathment; cell maturation; inflammatory response; integrin-mediated signaling pathway; long-chain fatty acid biosynthetic process; myelination in the central nervous system; substantia nigra development; synaptic transmission Disease: Pelizaeus-merzbacher Disease; Spastic Paraplegia 2, X-linked |
| NCBI Summary: | This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015] |
| UniProt Code: | P60201 |
| NCBI GenInfo Identifier: | 41349499 |
| NCBI Gene ID: | 5354 |
| NCBI Accession: | NP_000524.3 |
| UniProt Secondary Accession: | P60201,P04400, P06905, Q502Y1, Q6FHZ6, |
| UniProt Related Accession: | P60201 |
| Molecular Weight: | 26,274 Da |
| NCBI Full Name: | myelin proteolipid protein isoform 1 |
| NCBI Synonym Full Names: | proteolipid protein 1 |
| NCBI Official Symbol: | PLP1 |
| NCBI Official Synonym Symbols: | PLP; PMD; HLD1; MMPL; SPG2; GPM6C; PLP/DM20 |
| NCBI Protein Information: | myelin proteolipid protein |
| UniProt Protein Name: | Myelin proteolipid protein |
| UniProt Synonym Protein Names: | Lipophilin |
| Protein Family: | Proteolipid protein |
| UniProt Gene Name: | PLP1 |
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