Anti-PIEZO1 Antibody (CAB4340)
- SKU:
- CAB4340
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-PIEZO1 Antibody |
抗体コード: | CAB4340 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 2230-2420 of human PIEZO1 (NP_001136336.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | U-87MG, LO2, MCF7 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 2230-2420 of human PIEZO1 (NP_001136336.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | PSII PFTA QAYE ELSR QFDP QPLA MQFI SQYS PEDI VTAQ IEGS SGAL WRIS PPSR AQMK RELY NGTA DITL RFTW NFQR DLAK GGTV EYAN EKHM LALA PNST ARRQ LASL LEGT SDQS VVIP NLFP KYIR APNG PEAN PVKQ LQPN EEAD YLGV RIQL RREQ GAGA TGFL EWWV IELQ ECRT DCNL LPM |
遺伝子ID: | 9780 |
Uniprot: | Q92508 |
セルラーロケーション: | Cell membrane, Cell projection, Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Multi-pass membrane protein, lamellipodium membrane |
計算された分子量: | 286kDa |
観察された分子量: | 300kDa |
同義語: | PIEZO1, DHS, FAM38A, LMPH3, Mib |
バックグラウンド: | The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. |
UniProt Protein Function: | PIEZO1: Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. Belongs to the PIEZO family. |
UniProt Protein Details: | Protein type:Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 16q24.3 Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; endoplasmic reticulum; integral to membrane; plasma membrane Molecular Function:mechanically-gated ion channel activity; cation channel activity Biological Process: regulation of membrane potential; detection of mechanical stimulus; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of integrin activation; cation transport Disease: Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/or Perinatal Edema |
NCBI Summary: | Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010] |
UniProt Code: | Q92508 |
NCBI GenInfo Identifier: | 317373533 |
NCBI Gene ID: | 9780 |
NCBI Accession: | Q92508.4 |
UniProt Secondary Accession: | Q92508,Q0KKZ9, A6NHT9, A7E2B7, |
UniProt Related Accession: | Q92508 |
Molecular Weight: | 2521 |
NCBI Full Name: | Piezo-type mechanosensitive ion channel component 1 |
NCBI Synonym Full Names: | piezo-type mechanosensitive ion channel component 1 |
NCBI Official Symbol: | PIEZO1 |
NCBI Official Synonym Symbols: | DHS; Mib; FAM38A |
NCBI Protein Information: | piezo-type mechanosensitive ion channel component 1; family with sequence similarity 38, member A; membrane protein induced by beta-amyloid treatment |
UniProt Protein Name: | Piezo-type mechanosensitive ion channel component 1 |
UniProt Synonym Protein Names: | Membrane protein induced by beta-amyloid treatment; Mib; Protein FAM38A |
Protein Family: | Piezo-type mechanosensitive ion channel component |
UniProt Gene Name: | PIEZO1 |
UniProt Entry Name: | PIEZ1_HUMAN |
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