Anti-PHKA1 Antibody (CAB15700)
- SKU:
- CAB15700
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-PHKA1 Antibody |
抗体コード: | CAB15700 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-820 of human PHKA1 (NP_001116142.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | U-87MG, Jurkat, HeLa, Mouse heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-820 of human PHKA1 (NP_001116142.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | QTGK LSEF LTTS CCTH LSFM DPGP EGKL YSED YDDN YDYL ESGN WMND YDST SHAR CGDE VARY LDHL LAHT APHP KLAP TSQK GGLD RFQA AVQT TCDL MSLV TKAK ELHV QNVH MYLP TKLF QASR PSFN LLDS PHPR QENQ VPSV RVEI HLPR DQSG EVDF KALV LQLK ETSS LQEQ ADIL YMLY TMKG PDWN TELY NERS ATVR ELLT ELYG KVGE I |
遺伝子ID: | 5255 |
Uniprot: | P46020 |
セルラーロケーション: | Cell membrane, Cytoplasmic side, Lipid-anchor |
計算された分子量: | 129kDa/135kDa/137kDa |
観察された分子量: | 137kDa |
同義語: | PHKA1, PHKA |
バックグラウンド: | Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1. |
NCBI Summary: | Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.[provided by RefSeq, Feb 2010] |
UniProt Code: | P46020 |
NCBI GenInfo Identifier: | 169881275 |
NCBI Gene ID: | 5255 |
NCBI Accession: | NP_001116142 |
UniProt Related Accession: | P46020 |
Molecular Weight: | 129kDa; 135kDa; 137kDa |
NCBI Full Name: | phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform 2 |
NCBI Synonym Full Names: | phosphorylase kinase regulatory subunit alpha 1 |
NCBI Official Symbol: | PHKA1 |
NCBI Official Synonym Symbols: | PHKA |
NCBI Protein Information: | phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform |
UniProt Protein Name: | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform |
Protein Family: | Phosphorylase b kinase regulatory |
UniProt Gene Name: | PHKA1 |
UniProt Entry Name: | KPB1_HUMAN |
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