Anti-PFKL Antibody (CAB15080)
- SKU:
- CAB15080
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-PFKL Antibody |
抗体コード: | CAB15080 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | IF |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 601-780 of human PFKL (NP_002617.3). |
申し込み: | IF |
推奨希釈: | IF 1:50 - 1:200 |
反応性: | Human |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 601-780 of human PFKL (NP_002617.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | IHDL KVNV EHMT EKMK TDIQ RGLV LRNE KCHD YYTT EFLY NLYS SEGK GVFD CRTN VLGH LQQG GAPT PFDR NYGT KLGV KAML WLSE KLRE VYRK GRVF ANAP DSAC VIGL KKKA VAFS PVTE LKKD TDFE HRMP REQW WLSL RLML KMLA QYRI SMAA YVSG ELEH VTRR TLSM DKGF |
遺伝子ID: | 5211 |
Uniprot: | P17858 |
セルラーロケーション: | Cytoplasm |
計算された分子量: | 85kDa/90kDa |
観察された分子量: |
同義語: | PFKL, ATP-PFK, PFK-B, PFK-L |
バックグラウンド: | This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1, 6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | PFKL: phosphofructokinase, liver type. An ubiquitous metabolic enzyme involved in the synthesis and degradation of fructose 2,6-bisphosphate. Key control step of glycolysis. An allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate. Activity: ATP D-fructose 6-phosphate = ADP D-fructose 1,6-bisphosphate. The holoenzyme consists of 4 subunits. The liver and muscle enzymes are homo-tetramers of four liver or muscle isoforms, respectively. The red blood cell enzyme consists hetero-tetramers of the muscle and liver isoforms. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Kinase, other; EC 2.7.1.11; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: 6-phosphofructokinase complex; cytosol; membrane Molecular Function:6-phosphofructokinase activity; ATP binding; identical protein binding; kinase binding; protein binding Biological Process: fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; glycolysis; protein oligomerization; response to glucose stimulus |
NCBI Summary: | This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
UniProt Code: | P17858 |
NCBI GenInfo Identifier: | 134048493 |
NCBI Gene ID: | 5211 |
NCBI Accession: | P17858.6 |
UniProt Secondary Accession: | P17858,Q96A64, Q96IH4, Q9BR91, |
UniProt Related Accession: | P17858 |
Molecular Weight: | 90,203 Da |
NCBI Full Name: | ATP-dependent 6-phosphofructokinase, liver type |
NCBI Synonym Full Names: | phosphofructokinase, liver type |
NCBI Official Symbol: | PFKL |
NCBI Official Synonym Symbols: | PFK-B; PFK-L; ATP-PFK |
NCBI Protein Information: | ATP-dependent 6-phosphofructokinase, liver type |
UniProt Protein Name: | ATP-dependent 6-phosphofructokinase, liver type |
UniProt Synonym Protein Names: | 6-phosphofructokinase type B; Phosphofructo-1-kinase isozyme B; PFK-B; Phosphohexokinase |
Protein Family: | ATP-dependent 6-phosphofructokinase |
UniProt Gene Name: | PFKL |
UniProt Entry Name: | PFKAL_HUMAN |
Immunofluorescence analysis of U2OS cells using PFKL antibody (CAB15080) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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