Anti-PELI3 Antibody (CAB9999)
- SKU:
- CAB9999
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-PELI3 Antibody |
抗体コード: | CAB9999 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PELI3 (NP_659502.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | HepG2, A-549, SGC-7901, HeLa |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PELI3 (NP_659502.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MVLE GNPE VGSP RTSD LQHR GNKG SCVL SSPG EDAQ PGEE PIKY GELI VLGC CEEG GEET EAQR GEVT GPRA HSCY NGCL ASGD KGRR RSRL ALSR RSHA NGVK PDVM HHIS TPLV SKAL SNRG QHSI SYTL SRSH SVIV EYTH DSDT DMFQ IGRS TENM IDFV VTDT SPGG GAAE GPSA QSTI SRYA CRIL CDRR PPYT ARIY AAGF DASS NIFL GERA AKWR TPDG LMDG LTTN GVLV MHPA GGFS EDSA PGVW REIS VCGN VYTL RDSR SAQQ RGKL |
遺伝子ID: | 246330 |
Uniprot: | Q8N2H9 |
セルラーロケーション: | |
計算された分子量: | 35kDa/43kDa/48kDa/50kDa |
観察された分子量: | 50kDa |
同義語: | PELI3 |
バックグラウンド: | The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | PELI3: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. Belongs to the pellino family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: cytosol Molecular Function:protein binding; protein serine/threonine kinase activity Biological Process: immune response; Toll signaling pathway |
NCBI Summary: | The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] |
UniProt Code: | Q8N2H9 |
NCBI GenInfo Identifier: | 37999712 |
NCBI Gene ID: | 246330 |
NCBI Accession: | Q8N2H9.2 |
UniProt Secondary Accession: | Q8N2H9,Q8N3E1, Q8N9Q6, Q8TAW7, Q8TED5, |
UniProt Related Accession: | Q8N2H9 |
Molecular Weight: | 51kDa |
NCBI Full Name: | E3 ubiquitin-protein ligase pellino homolog 3 |
NCBI Synonym Full Names: | pellino E3 ubiquitin protein ligase family member 3 |
NCBI Official Symbol: | PELI3 |
NCBI Protein Information: | E3 ubiquitin-protein ligase pellino homolog 3 |
UniProt Protein Name: | E3 ubiquitin-protein ligase pellino homolog 3 |
UniProt Synonym Protein Names: | RING-type E3 ubiquitin transferase pellino homolog 3Curated |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | PELI3 |
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