Anti-PEG3 Antibody (CAB12671)
- SKU:
- CAB12671
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
抗体名: | Anti-PEG3 Antibody |
抗体コード: | CAB12671 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PEG3 (NP_006201.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HepG2 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PEG3 (NP_006201.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MLPP KHLS ATKP KKSW APNL YELD SDLT KEPD VIIG EGPT DSEF FHQR FRNL IYVE FVGP RKTL IKLR NLCL DWLQ PETR TKEE IIEL LVLE QYLT IIPE KLKP WVRA KKPE NCEK LVTL LENY KEMY QPED DNNS DVTS DDDM TRNR RESS PPHS VHSF SDRD WDRR GRSR DMEP RDRW SHTR NPRS RMPP RDLS LPVV AKTS FEMD REDD RDSR AYES RSQD AESY QNVV DLAE DRKP HNTI QDNM ENYR KLLS LVQL AEDD GHSH MTQG HSSR SKRS AYPS TSRG LKTM PEAK KSTH |
遺伝子ID: | 5178 |
Uniprot: | Q9GZU2 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 60kDa/165kDa/166kDa/180kDa |
観察された分子量: | 181KDa |
同義語: | PEG3, PW1, ZKSCAN22, ZNF904, ZSCAN24 |
バックグラウンド: | In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. |
UniProt Protein Function: | Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumor suppressing activity in glioma cells. |
NCBI Summary: | In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009] |
UniProt Code: | Q9GZU2 |
NCBI GenInfo Identifier: | 226053126 |
NCBI Gene ID: | 5178 |
NCBI Accession: | NP_001139656.1 |
UniProt Secondary Accession: | Q9GZU2,P78418, Q5H9P9, Q7Z7H7, Q8TF75, Q9GZY2, A7E2B8 B4DIM4, C9JP50, |
UniProt Related Accession: | Q9GZU2 |
Molecular Weight: | |
NCBI Full Name: | paternally-expressed gene 3 protein isoform 1 |
NCBI Synonym Full Names: | paternally expressed 3 |
NCBI Official Symbol: | PEG3 |
NCBI Official Synonym Symbols: | PW1; ZNF904; ZSCAN24; ZKSCAN22 |
NCBI Protein Information: | paternally-expressed gene 3 protein |
UniProt Protein Name: | Paternally-expressed gene 3 protein |
UniProt Synonym Protein Names: | Zinc finger and SCAN domain-containing protein 24 |
Protein Family: | Paternally-expressed gene 3 protein |
UniProt Gene Name: | PEG3 |
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