Anti-PARP2 Antibody (CAB16475)
- SKU:
- CAB16475
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-PARP2 Antibody |
抗体コード: | CAB16475 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 450-550 of human PARP2 (NP_001036083.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 450-550 of human PARP2 (NP_001036083.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | FADM SSKS ANYC FASR LKNT GLLL LSEV ALGQ CNEL LEAN PKAE GLLQ GKHS TKGL GKMA PSSA HFVT LNGS TVPL GPAS DTGI LNPD GYTL NYNE YIVY N |
遺伝子ID: | 10038 |
Uniprot: | Q9UGN5 |
セルラーロケーション: | Nucleus |
計算された分子量: | 64kDa/66kDa |
観察された分子量: | Refer to figures |
同義語: | PARP2, ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2 |
バックグラウンド: | This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. |
UniProt Protein Function: | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). |
NCBI Summary: | This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UGN5 |
NCBI GenInfo Identifier: | 110825961 |
NCBI Gene ID: | 10038 |
NCBI Accession: | NP_005475 |
UniProt Secondary Accession: | Q9UGN5,Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8, |
UniProt Related Accession: | Q9UGN5 |
Molecular Weight: | 42.5 kDa (376aa) |
NCBI Full Name: | poly |
NCBI Synonym Full Names: | poly(ADP-ribose) polymerase 2 |
NCBI Official Symbol: | PARP2 |
NCBI Official Synonym Symbols: | ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2 |
NCBI Protein Information: | poly [ADP-ribose] polymerase 2 |
UniProt Protein Name: | Poly [ADP-ribose] polymerase 2 |
UniProt Synonym Protein Names: | ADP-ribosyltransferase diphtheria toxin-like 2; ARTD2; NAD(+) ADP-ribosyltransferase 2; ADPRT-2; Poly[ADP-ribose] synthase 2; pADPRT-2 |
Protein Family: | Poly [ADP-ribose] polymerase |
UniProt Gene Name: | PARP2 |
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