Anti-PABPN1 Antibody (CAB6041)
- SKU:
- CAB6041
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Polyclonal AntibodyPN1 Rabbit Polyclonal Antibody |
抗体コード: | CAB6041 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PABPN1 (NP_004634.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:1000 |
反応性: | Human, Mouse |
ポジティブサンプル: | B cells, HeLa, HepG2, U-87MG, Mouse brain, Mouse testis |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PABPN1 (NP_004634.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAAA AAAA AAAG AAGG RGSG PGRR RHLV PGAG GEAG EGAP GGAG DYGN GLES EELE PEEL LLEP EPEP EPEE EPPR PRAP PGAP GPGP GSGA PGSQ EEEE |
遺伝子ID: | 8106 |
Uniprot: | Q86U42 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 31kDa/32kDa/37kDa |
観察された分子量: | 45kDa |
同義語: | PABPN1, OPMD, PAB2, PABII, PABP-2, PABP2 |
バックグラウンド: | This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. |
UniProt Code: | Q86U42 |
NCBI GenInfo Identifier: | 46403176 |
NCBI Gene ID: | 8106 |
NCBI Accession: | Q86U42.3 |
UniProt Secondary Accession: | Q86U42,O43484, D3DS49, |
UniProt Related Accession: | Q86U42 |
Molecular Weight: | 306 |
NCBI Full Name: | Polyadenylate-binding protein 2 |
NCBI Synonym Full Names: | poly(A) binding protein, nuclear 1 |
NCBI Official Symbol: | PABPN1 |
NCBI Official Synonym Symbols: | OPMD; PAB2; PABII; PABP2; PABP-2 |
NCBI Protein Information: | polyadenylate-binding protein 2; poly(A) binding protein 2; poly(A) binding protein II |
UniProt Protein Name: | Polyadenylate-binding protein 2 |
UniProt Synonym Protein Names: | Nuclear poly(A)-binding protein 1; Poly(A)-binding protein II; PABII; Polyadenylate-binding nuclear protein 1 |
UniProt Gene Name: | PABPN1 |
UniProt Entry Name: | PABP2_HUMAN |
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