Anti-OX40 Antibody (CAB3646)
- SKU:
- CAB3646
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
抗体名: | Anti-OX40 Antibody |
抗体コード: | CAB3646 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human OX40 (NP_003318.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Rat |
ポジティブサンプル: | Rat liver |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human OX40 (NP_003318.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | TATQ DTVC RCRA GTQP LDSY KPGV DCAP CPPG HFSP GDNQ ACKP WTNC TLAG KHTL QPAS NSSD AICE DRDP PATQ PQET QGPP ARPI TVQP TEAW PRTS Q |
遺伝子ID: | 7293 |
Uniprot: | P43489 |
セルラーロケーション: | Membrane, Single-pass type I membrane protein |
計算された分子量: | 29kDa |
観察された分子量: | 48kDa |
同義語: | TNFRSF4, ACT35, CD134, IMD16, OX40, TXGP1L |
バックグラウンド: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. |
UniProt Protein Function: | TNFRSF4: Receptor for TNFSF4/OX40L/GP34. |
UniProt Protein Details: | Protein type:Apoptosis; Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p36 Cellular Component: cell surface; integral to plasma membrane; external side of plasma membrane Molecular Function:tumor necrosis factor receptor activity Biological Process: T cell proliferation; regulation of apoptosis; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription factor activity; negative regulation of cytokine secretion; positive regulation of B cell proliferation; cellular defense response; immune response; positive regulation of immunoglobulin secretion; negative regulation of transcription, DNA-dependent; inflammatory response; regulation of protein kinase activity Disease: Immunodeficiency 16 |
NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008] |
UniProt Code: | P43489 |
NCBI GenInfo Identifier: | 1171933 |
NCBI Gene ID: | 7293 |
NCBI Accession: | P43489.1 |
UniProt Related Accession: | P43489 |
Molecular Weight: | |
NCBI Full Name: | Tumor necrosis factor receptor superfamily member 4 |
NCBI Synonym Full Names: | TNF receptor superfamily member 4 |
NCBI Official Symbol: | TNFRSF4 |
NCBI Official Synonym Symbols: | OX40; ACT35; CD134; IMD16; TXGP1L |
NCBI Protein Information: | tumor necrosis factor receptor superfamily member 4 |
UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 4 |
UniProt Synonym Protein Names: | ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD_antigen: CD134 |
UniProt Gene Name: | TNFRSF4 |
UniProt Entry Name: | TNR4_HUMAN |