Anti-OPRL1 Antibody (CAB3113)
- SKU:
- CAB3113
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-OPRL1 Antibody |
抗体コード: | CAB3113 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | A synthetic peptide of human OPRL1 |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | K-562, SW620, NCI-H460, U-87MG |
免疫原: | A synthetic peptide of human OPRL1 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 4987 |
Uniprot: | P41146 |
セルラーロケーション: | Cell membrane, Cytoplasmic vesicle, Multi-pass membrane protein |
計算された分子量: | 40kDa |
観察された分子量: | 50kDa |
同義語: | OPRL1, KOR-3, NOCIR, NOP, NOPr, OOR, ORL1 |
バックグラウンド: | The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. |
UniProt Protein Function: | KOR-3: Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1 Chromosomal Location of Human Ortholog: 20q13.33 Cellular Component: neuron projection; integral to plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane Molecular Function:G-protein coupled receptor activity; neuropeptide binding; protein binding; nociceptin/orphanin-FQ receptor activity Biological Process: synaptic transmission; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; sensory perception; behavior; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain |
NCBI Summary: | The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017] |
UniProt Code: | P41146 |
NCBI GenInfo Identifier: | 730230 |
NCBI Gene ID: | 4987 |
NCBI Accession: | P41146.1 |
UniProt Related Accession: | P41146 |
Molecular Weight: | |
NCBI Full Name: | Nociceptin receptor |
NCBI Synonym Full Names: | opioid related nociceptin receptor 1 |
NCBI Official Symbol: | OPRL1 |
NCBI Official Synonym Symbols: | NOP; OOR; NOPr; ORL1; KOR-3; NOCIR |
NCBI Protein Information: | nociceptin receptor |
UniProt Protein Name: | Nociceptin receptor |
UniProt Synonym Protein Names: | Kappa-type 3 opioid receptor; KOR-3; Orphanin FQ receptor |
UniProt Gene Name: | OPRL1 |
UniProt Entry Name: | OPRX_HUMAN |
View AllClose