Anti-OAZ1 Antibody (CAB7444)
- SKU:
- CAB7444
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-OAZ1 Antibody |
抗体コード: | CAB7444 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-68 of human OAZ1 (NP_004143.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | MCF7, Mouse heart, Rat kidney |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-68 of human OAZ1 (NP_004143.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MVKS SLQR ILNS HCFA REKE GDKP SATI HASR TMPL LSLH SRGG SSSE SSRV SLHC CSNP GPGP RWCS |
遺伝子ID: | 4946 |
Uniprot: | P54368 |
セルラーロケーション: | |
計算された分子量: | 25kDa |
観察された分子量: | 27kDa |
同義語: | OAZ1, AZ1, AZI, OAZ |
バックグラウンド: | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. |
UniProt Protein Function: | OAZ1: Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Belongs to the ODC antizyme family. 1 isoforms of the human protein are produced by ribosomal frameshifting. |
UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytosol Molecular Function:protein binding; ornithine decarboxylase inhibitor activity Biological Process: transport; polyamine biosynthetic process; negative regulation of catalytic activity; positive regulation of protein catabolic process; regulation of amino acid metabolic process |
NCBI Summary: | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014] |
UniProt Code: | P54368 |
NCBI GenInfo Identifier: | 1709427 |
NCBI Gene ID: | 4946 |
NCBI Accession: | P54368.3 |
UniProt Secondary Accession: | P54368,O43382, Q14989, Q92595, Q9UPL9, |
UniProt Related Accession: | P54368 |
Molecular Weight: | 228 |
NCBI Full Name: | Ornithine decarboxylase antizyme 1 |
NCBI Synonym Full Names: | ornithine decarboxylase antizyme 1 |
NCBI Official Symbol: | OAZ1 |
NCBI Official Synonym Symbols: | AZI; OAZ |
NCBI Protein Information: | ornithine decarboxylase antizyme 1; ODC-Az |
UniProt Protein Name: | Ornithine decarboxylase antizyme 1 |
Protein Family: | Ornithine decarboxylase antizyme |
UniProt Gene Name: | OAZ1 |
UniProt Entry Name: | OAZ1_HUMAN |
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