Anti-NT5C3A Antibody (CAB7593)
- SKU:
- CAB7593
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-NT5C3A Antibody |
抗体コード: | CAB7593 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-336 of human NT5C3A (NP_001002010.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | Mouse heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-336 of human NT5C3A (NP_001002010.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | TLKR KTGR KTKI IEMM PEFQ KSSV RIKN PTRV EEII CGLI KGGA AKLQ IITD FDMT LSRF SYKG KRCP TCHN IIDN CKLV TDEC RKKL LQLK EKYY AIEV DPVL TVEE KYPY MVEW YTKS HGLL VQQA LPKA KLKE IVAE SDVM LKEG YENF FDKL QQHS IPVF IFSA GIGD VLEE VIRQ AGVY HPNV KVVS NFMD FDET GVLK GFKG ELIH VFNK HDGA LRNT EYFN QLKD NSNI ILLG DSQG DLRM ADGV ANVE HILK IGYL NDRV DELL EKYM DSYD IVLV QDES LEVA NSIL QKIL |
遺伝子ID: | 51251 |
Uniprot: | Q9H0P0 |
セルラーロケーション: | Cytoplasm, Endoplasmic reticulum |
計算された分子量: | 32kDa/33kDa/37kDa |
観察された分子量: | 38kDa |
同義語: | NT5C3A, NT5C3, P5N-1, PN-I, POMP, PSN1, UMPH, UMPH1, cN-III, hUMP1, p36 |
バックグラウンド: | This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. |
UniProt Protein Function: | NT5C3A: Can act both as nucleotidase and as phosphotransferase. Defects in NT5C3 are the cause of P5N deficiency (P5ND); also called hemolytic anemia due to P5N deficiency or hemolytic anemia due to UMPH1 deficiency. P5ND is an autosomal recessive condition causing hemolytic anemia characterized by marked basophilic stipplig and the accumulation of high concentrations of pyrimidine nucleotides within the erythrocyte. It is implicated in the anemia of lead poisoning and is possibly associated with learning difficulties. Belongs to the pyrimidine 5'-nucleotidase family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nucleotide Metabolism - pyrimidine; Phosphatase (non-protein); Transferase; EC 3.1.3.5; Endoplasmic reticulum; Nucleotide Metabolism - purine; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide Chromosomal Location of Human Ortholog: 7p14.3 Cellular Component: cytoplasm; cytosol; endoplasmic reticulum Molecular Function:2'-phosphotransferase activity; 5'-nucleotidase activity Biological Process: pyrimidine nucleoside catabolic process Disease: Uridine 5-prime Monophosphate Hydrolase Deficiency, Hemolytic Anemia Due To |
NCBI Summary: | This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012] |
UniProt Code: | Q9H0P0 |
NCBI GenInfo Identifier: | 117949804 |
NCBI Gene ID: | 51251 |
NCBI Accession: | Q9H0P0.3 |
UniProt Secondary Accession: | Q9H0P0,Q6IPZ1, Q6NXS6, Q7L3G6, Q9P0P5, Q9UC42, Q9UC43 Q9UC44, Q9UC45, A8K253, B2RAA5, B8ZZC4, |
UniProt Related Accession: | Q9H0P0 |
Molecular Weight: | 32,559 Da |
NCBI Full Name: | Cytosolic 5'-nucleotidase 3A |
NCBI Synonym Full Names: | 5'-nucleotidase, cytosolic IIIA |
NCBI Official Symbol: | NT5C3A |
NCBI Official Synonym Symbols: | p36; PN-I; POMP; PSN1; UMPH; NT5C3; P5N-1; UMPH1; hUMP1; P5'N-1; cN-III |
NCBI Protein Information: | cytosolic 5'-nucleotidase 3A |
UniProt Protein Name: | Cytosolic 5'-nucleotidase 3A |
UniProt Synonym Protein Names: | 7-methylguanosine phosphate-specific 5'-nucleotidase |
Protein Family: | Cytosolic 5'-nucleotidase |
UniProt Gene Name: | NT5C3A |
UniProt Entry Name: | 5NT3A_HUMAN |
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