Anti-NMNAT3 Antibody (CAB14465)
- SKU:
- CAB14465
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-NMNAT3 Antibody |
抗体コード: | CAB14465 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human NMNAT3 (NP_835471.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Mouse heart, Mouse kidney, Rat heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human NMNAT3 (NP_835471.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MYQV IQGI ISPV NDTY GKKD LAAS HHRV AMAR LALQ TSDW IRVD PWES EQAQ WMET VKVL RHHH SKLL RSPP QMEG PDHG KALF STPA AVPE LKLL CGAD VLKT FQTP NLWK DAHI QEIV EKFG LVCV GRVG HDPK GYIA ESPI LRMH QHNI HLAK EPVQ NEIS ATYI RRAL GQGQ SVKY LIPD AVIT YIKD HGLY TKGS TWKG KSTQ STEG KTS |
遺伝子ID: | 349565 |
Uniprot: | Q96T66 |
セルラーロケーション: | Mitochondrion |
計算された分子量: | 18kDa/24kDa/28kDa |
観察された分子量: | 28kDa |
同義語: | NMNAT3, FKSG76, PNAT-3, PNAT3 |
バックグラウンド: | This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
UniProt Protein Function: | NMNAT3: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury. Belongs to the eukaryotic NMN adenylyltransferase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.7.7.1; EC 2.7.7.18; Apoptosis; Mitochondrial; Transferase Chromosomal Location of Human Ortholog: 3q23 Cellular Component: cytosol; mitochondrion Molecular Function:nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity Biological Process: NAD biosynthetic process; NAD metabolic process |
NCBI Summary: | This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
UniProt Code: | Q96T66 |
NCBI GenInfo Identifier: | 116242680 |
NCBI Gene ID: | 349565 |
NCBI Accession: | Q96T66.2 |
UniProt Secondary Accession: | Q96T66,Q8N4G1, B3KVR6, D3DNF2, D3DNF3, |
UniProt Related Accession: | Q96T66 |
Molecular Weight: | 18,255 Da |
NCBI Full Name: | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 |
NCBI Synonym Full Names: | nicotinamide nucleotide adenylyltransferase 3 |
NCBI Official Symbol: | NMNAT3 |
NCBI Official Synonym Symbols: | PNAT3; FKSG76; PNAT-3 |
NCBI Protein Information: | nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 |
UniProt Protein Name: | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 |
UniProt Synonym Protein Names: | Nicotinamide-nucleotide adenylyltransferase 3; NMN adenylyltransferase 3; Nicotinate-nucleotide adenylyltransferase 3 (EC:2.7.7.18); NaMN adenylyltransferase 3; Pyridine nucleotide adenylyltransferase 3 (EC:2.7.7.1); PNAT-3 |
Protein Family: | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase |
UniProt Gene Name: | NMNAT3 |
UniProt Entry Name: | NMNA3_HUMAN |
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