Anti-NMNAT2 Antibody (CAB13833)
- SKU:
- CAB13833
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-NMNAT2 Antibody |
抗体コード: | CAB13833 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human NMNAT2 (NP_733820.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG, NCI-H460, BxPC-3, Mouse pancreas, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human NMNAT2 (NP_733820.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MEIQ ELEE IQAC QGLW EVFV TLSE RARD YLHK TGRF IVIG GIVS PVHD SYGK QGLV SSRH RLIM CQLA VQNS DWIR VDPW ECYQ DTWQ TTCS VLEH HRDL MKRV TGCI LSNV NTPS MTPV IGQP QNET PQPI YQNS NVAT KPTA AKIL GKVG ESLS RICC VRPP VERF TFVD ENAN LGTV MRYE EIEL RILL LCGS DLLE SFCI PGLW NEAD MEVI VGDF GIVV VPRD AADT DRIM NHSS ILRK YKNN IMVV KDDI NHPM SVVS STKS RLAL QHGD GHVV DYLS QPVI DYIL KSQL YINA SG |
遺伝子ID: | 23057 |
Uniprot: | Q9BZQ4 |
セルラーロケーション: | Cytoplasm, Golgi apparatus |
計算された分子量: | 34kDa |
観察された分子量: | 37kDa |
同義語: | NMNAT2, C1orf15, PNAT2 |
バックグラウンド: | This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | NMNAT2: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Belongs to the eukaryotic NMN adenylyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.7.7.1; EC 2.7.7.18; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Transferase Chromosomal Location of Human Ortholog: 1q25 Cellular Component: Golgi apparatus; Golgi membrane Molecular Function:nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity Biological Process: NAD biosynthetic process; NAD metabolic process |
NCBI Summary: | This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BZQ4 |
NCBI GenInfo Identifier: | 30580486 |
NCBI Gene ID: | 23057 |
NCBI Accession: | Q9BZQ4.1 |
UniProt Secondary Accession: | Q9BZQ4,O75067, Q5T1Q3, Q8WU99, Q96QW1, |
UniProt Related Accession: | Q9BZQ4 |
Molecular Weight: | 34,015 Da |
NCBI Full Name: | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 |
NCBI Synonym Full Names: | nicotinamide nucleotide adenylyltransferase 2 |
NCBI Official Symbol: | NMNAT2 |
NCBI Official Synonym Symbols: | PNAT2; C1orf15 |
NCBI Protein Information: | nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 |
UniProt Protein Name: | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 |
UniProt Synonym Protein Names: | Nicotinamide mononucleotide adenylyltransferase 2; NMN adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2; NaMN adenylyltransferase 2 |
UniProt Gene Name: | NMNAT2 |
UniProt Entry Name: | NMNA2_HUMAN |
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