Anti-NME2 Antibody (CAB7443)
- SKU:
- CAB7443
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
抗体名: | Anti-NME2 Antibody |
抗体コード: | CAB7443 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-152 of human NME2 (NP_001018148.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | PC-12, 22Rv1, Mouse kidney, Mouse liver, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-152 of human NME2 (NP_001018148.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MANL ERTF IAIK PDGV QRGL VGEI IKRF EQKG FRLV AMKF LRAS EEHL KQHY IDLK DRPF FPGL VKYM NSGP VVAM VWEG LNVV KTGR VMLG ETNP ADSK PGTI RGDF CIQV GRNI IHGS DSVK SAEK EISL WFKP EELV DYKS CAHD WVYE |
遺伝子ID: | 4831 |
Uniprot: | P22392 |
セルラーロケーション: | Cell projection, Cytoplasm, Nucleus, lamellipodium, ruffle |
計算された分子量: | 17kDa/30kDa |
観察された分子量: | 17kDa |
同義語: | NME2, NDKB, NDPK-B, NDPKB, NM23-H2, NM23B, PUF |
バックグラウンド: | Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. |
UniProt Protein Function: | NME2: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Belongs to the NDK family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; EC 2.7.13.3; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; Kinase, nucleoside diphosphate; Kinase, other; EC 2.7.4.6; Other group; NDK family Chromosomal Location of Human Ortholog: 17q21.3 Cellular Component: cytoplasm; cytosol; focal adhesion; lamellipodium; nucleus; ruffle Molecular Function:nucleoside diphosphate kinase activity; protein binding; transcription factor activity Biological Process: cell adhesion; integrin-mediated signaling pathway; negative regulation of apoptosis; nucleobase, nucleoside and nucleotide interconversion; nucleoside triphosphate biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; purine nucleotide metabolic process; pyrimidine nucleotide metabolic process; regulation of epidermis development; regulation of transcription, DNA-dependent |
NCBI Summary: | Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010] |
UniProt Code: | P22392 |
NCBI GenInfo Identifier: | 127983 |
NCBI Gene ID: | 4831 |
NCBI Accession: | P22392.1 |
UniProt Secondary Accession: | P22392,Q1WM23, Q6LCT6, A8MWA3, |
UniProt Related Accession: | P22392 |
Molecular Weight: | 30,137 Da |
NCBI Full Name: | Nucleoside diphosphate kinase B |
NCBI Synonym Full Names: | NME/NM23 nucleoside diphosphate kinase 2 |
NCBI Official Symbol: | NME2 |
NCBI Official Synonym Symbols: | PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2 |
NCBI Protein Information: | nucleoside diphosphate kinase B |
UniProt Protein Name: | Nucleoside diphosphate kinase B |
UniProt Synonym Protein Names: | C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB (EC:2.7.13.3); nm23-H2 |
UniProt Gene Name: | NME2 |
UniProt Entry Name: | NDKB_HUMAN |