Anti-NKAP Antibody (CAB13748)
- SKU:
- CAB13748
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-NKAP Antibody |
抗体コード: | CAB13748 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human NKAP (NP_078804.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | A-431 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human NKAP (NP_078804.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAPV SGSR SPDR EASG SGGR RRSS SKSP KPSK SARS PRGR RSRS HSCS RSGD RNGL THQL GGLS QGSR NQSY RSRS RSRS RERP SAPR GIPF ASAS SSVY YGSY SRPY GSDK PWPS LLDK EREE SLRQ KR |
遺伝子ID: | 79576 |
Uniprot: | Q8N5F7 |
セルラーロケーション: | Nucleus |
計算された分子量: | 47kDa |
観察された分子量: | 47kDa |
同義語: | NKAP |
バックグラウンド: | This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. |
UniProt Protein Function: | NKAP: Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. Belongs to the UPF0396 family. |
UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: Xq24 Cellular Component: cytoplasm; nucleoplasm Molecular Function:chromatin binding; protein binding Biological Process: negative regulation of transcription, DNA-dependent; positive regulation of alpha-beta T cell differentiation |
NCBI Summary: | This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010] |
UniProt Code: | Q8N5F7 |
NCBI GenInfo Identifier: | 74728990 |
NCBI Gene ID: | 79576 |
NCBI Accession: | Q8N5F7.1 |
UniProt Secondary Accession: | Q8N5F7,Q6IPW6, Q96BQ2, Q9H638, |
UniProt Related Accession: | Q8N5F7 |
Molecular Weight: | 47,138 Da |
NCBI Full Name: | NF-kappa-B-activating protein |
NCBI Synonym Full Names: | NFKB activating protein |
NCBI Official Symbol: | NKAP |
NCBI Protein Information: | NF-kappa-B-activating protein |
UniProt Protein Name: | NF-kappa-B-activating protein |
Protein Family: | NKAP-like protein |
UniProt Gene Name: | NKAP |
UniProt Entry Name: | NKAP_HUMAN |
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