Anti-NBEAL2 Antibody (CAB15797)
- SKU:
- CAB15797
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-NBEAL2 Antibody |
抗体コード: | CAB15797 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1800-2100 of human NBEAL2 (NP_055990.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | HeLa |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1800-2100 of human NBEAL2 (NP_055990.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LLHW GALW RQLA SPCG AWAL RDTP IPRW KLSS AETY SRMR LKLV PNHH FDPH LEAS ALRD NLGE VPLT PTEE ASLP LAVT KEAK VSTP PELL QEDQ LGED ELAE LETP MEAA ELDE QREK LVLS AECQ LVTV VAVV PGLL EVTT QNVY FYDG STER VETE EGIG YDFR RPLA QLRE VHLR RFNL RRSA LELF FIDQ ANYF LNFP CKVG TTPV SSPS QTPR PQPG PIPP HTQV RNQV YSWL LRLR PPSQ GYLS SRSP QEML RASG LTQK WVQR EISN FEYL MQLN TIAG RTYN DLSQ YPVF P |
遺伝子ID: | 23218 |
Uniprot: | Q6ZNJ1 |
セルラーロケーション: | Endoplasmic reticulum |
計算された分子量: | 282kDa/299kDa/302kDa |
観察された分子量: | 302kDa |
同義語: | NBEAL2, BDPLT4, GPS |
バックグラウンド: | The protein encoded by this gene contains a beige and Chediak-Higashi (BEACH) domain and multiple WD40 domains, and may play a role in megakaryocyte alpha-granule biogenesis. Mutations in this gene are a cause of gray platelet syndrome. |
UniProt Protein Function: | NBEAL2: Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. Defects in NBEAL2 are the cause of gray platelet syndrome (GPS). GPS is a rare platelet disorder characterized by a selective deficiency in the number and contents of platelet alpha-granules. It is associated with mild to moderate bleeding tendency and moderate thrombocytopenia. The platelets are enlarged and have a gray appearance on light microscopy of Wright-stained peripheral blood smears due to decreased granules. Belongs to the WD repeat neurobeachin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: endoplasmic reticulum; extrinsic to membrane Molecular Function:phospholipid binding Biological Process: platelet formation Disease: Gray Platelet Syndrome |
NCBI Summary: | The protein encoded by this gene contains a beige and Chediak-Higashi (BEACH) domain and multiple WD40 domains, and may play a role in megakaryocyte alpha-granule biogenesis. Mutations in this gene are a cause of gray platelet syndrome. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q6ZNJ1 |
NCBI GenInfo Identifier: | 149944548 |
NCBI Gene ID: | 23218 |
NCBI Accession: | NP_055990.1 |
UniProt Secondary Accession: | Q6ZNJ1,O60288, Q6P994, Q6UX91, Q8NAC9, |
UniProt Related Accession: | Q6ZNJ1 |
Molecular Weight: | 299,342 Da |
NCBI Full Name: | neurobeachin-like protein 2 |
NCBI Synonym Full Names: | neurobeachin like 2 |
NCBI Official Symbol: | NBEAL2 |
NCBI Official Synonym Symbols: | GPS; BDPLT4 |
NCBI Protein Information: | neurobeachin-like protein 2 |
UniProt Protein Name: | Neurobeachin-like protein 2 |
Protein Family: | Neurobeachin-like protein |
UniProt Gene Name: | NBEAL2 |
UniProt Entry Name: | NBEL2_HUMAN |
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