Anti-MYF6 Antibody (CAB15291)
- SKU:
- CAB15291
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
抗体名: | Anti-MYF6 Antibody |
抗体コード: | CAB15291 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-180 of human MYF6 (NP_002460.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HepG2, Mouse skeletal muscle, Mouse spleen, Rat skeletal muscle |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-180 of human MYF6 (NP_002460.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | WACK TCKR KSAP TDRR KAAT LRER RRLK KINE AFEA LKRR TVAN PNQR LPKV EILR SAIS YIER LQDL LHRL DQQE KMQE LGVD PFSY RPKQ ENLE GADF L |
遺伝子ID: | 4618 |
Uniprot: | P23409 |
セルラーロケーション: | Nucleus |
計算された分子量: | 26kDa |
観察された分子量: | 27kDa |
同義語: | MYF6, CNM3, MRF4, bHLHc4, myf-6 |
バックグラウンド: | The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). |
UniProt Protein Function: | Myf-6: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. Defects in MYF6 may be a cause of centronuclear myopathy type 3 (CNM3). A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q21 Cellular Component: nucleoplasm; nucleus Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; protein heterodimerization activity; transcription factor activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; muscle cell differentiation; skeletal muscle development; somitogenesis; positive regulation of skeletal muscle fiber development; muscle cell fate commitment; positive regulation of muscle cell differentiation; skeletal muscle regeneration; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of myoblast differentiation Disease: Myopathy, Centronuclear, 3 |
NCBI Summary: | The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010] |
UniProt Code: | P23409 |
NCBI GenInfo Identifier: | 4505299 |
NCBI Gene ID: | 4618 |
NCBI Accession: | NP_002460.1 |
UniProt Secondary Accession: | P23409,Q53X80, Q6FHI9, B2R898, |
UniProt Related Accession: | P23409 |
Molecular Weight: | |
NCBI Full Name: | myogenic factor 6 |
NCBI Synonym Full Names: | myogenic factor 6 (herculin) |
NCBI Official Symbol: | MYF6 |
NCBI Official Synonym Symbols: | CNM3; MRF4; myf-6; bHLHc4 |
NCBI Protein Information: | myogenic factor 6 |
UniProt Protein Name: | Myogenic factor 6 |
UniProt Synonym Protein Names: | Class C basic helix-loop-helix protein 4; bHLHc4; Muscle-specific regulatory factor 4 |
Protein Family: | Myogenic factor |
UniProt Gene Name: | MYF6 |
UniProt Entry Name: | MYF6_HUMAN |