Anti-MTMR3 Antibody (CAB10806)
- SKU:
- CAB10806
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-MTMR3 Antibody |
抗体コード: | CAB10806 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 640-810 of human MTMR3 (NP_066576.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
反応性: | Human, Mouse |
ポジティブサンプル: | U-87MG, HeLa, Jurkat, LO2 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 640-810 of human MTMR3 (NP_066576.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | KWQE HRRS LELS SLAG PGED PLSA DSLG KPTR VPGG AELS VAAG VAEG QMEN ILQE ATKE ESGV EEPA HRAG IEIQ EGKE DPLL EKES RRKT PEAS AIGL HQDP ELGD AALR SHLD MSWP LFSQ GISE QQSG LSVL LSSL QVPP RGED SLEV PVEQ FRIE EIAE GREE AVL |
遺伝子ID: | 8897 |
Uniprot: | Q13615 |
セルラーロケーション: | Cytoplasm, Membrane, Peripheral membrane protein |
計算された分子量: | 129kDa/130kDa/133kDa |
観察された分子量: | 134kDa |
同義語: | MTMR3, FYVE-DSP1, ZFYVE10 |
バックグラウンド: | This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3, 5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | MTMR3: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.1.3.48; EC 3.1.3.64; EC 3.1.3.95; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 22q12.2 Cellular Component: cytoplasm; cytosol; extrinsic to membrane; membrane Molecular Function:phosphatidylinositol-3-phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity Biological Process: cellular response to glucose starvation; macroautophagy; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; protein amino acid dephosphorylation |
NCBI Summary: | This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13615 |
NCBI GenInfo Identifier: | 33112668 |
NCBI Gene ID: | 8897 |
NCBI Accession: | Q13615.3 |
UniProt Secondary Accession: | Q13615,Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3, A5PL26, A7MD32 |
UniProt Related Accession: | Q13615 |
Molecular Weight: | 134kDa |
NCBI Full Name: | Myotubularin-related protein 3 |
NCBI Synonym Full Names: | myotubularin related protein 3 |
NCBI Official Symbol: | MTMR3 |
NCBI Official Synonym Symbols: | ZFYVE10; FYVE-DSP1 |
NCBI Protein Information: | myotubularin-related protein 3 |
UniProt Protein Name: | Myotubularin-related protein 3 |
UniProt Synonym Protein Names: | FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95 |
UniProt Gene Name: | MTMR3 |
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