Anti-MTIF2 Antibody (CAB16402)
- SKU:
- CAB16402
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-MTIF2 Antibody |
抗体コード: | CAB16402 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 428-727 of human MTIF2 (NP_002444.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | LO2, A-431, U-251MG, Mouse heart, Mouse kidney, Mouse liver, Mouse spleen, Rat testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 428-727 of human MTIF2 (NP_002444.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | GEEI LEVE SEPR AREV VDWR KYEQ EQEK GQED LKII EEKR KEHK EAHQ KARE KYGH LLWK KRSI LRFL ERKE QIPL KPKE KRER DSNV LSVI IKGD VDGS VEAI LNII DTYD ASHE CELE LVHF GVGD VSAN DVNL AETF DGVI YGFN VNAG NVIQ QSAA KKGV KIKL HKII YRLV EDLQ EELS SRLP CAVE EHPV GEAS ILAT FSVT EGKK KVPV AGCR VQKG QLEK QKKF KLTR NGHV IWKG SLTS LKHH KDDI SIVK TGMD CGLS LDED NMEF QVGD RIVC YEEK QIQA KTSW DPGF |
遺伝子ID: | 4528 |
Uniprot: | P46199 |
セルラーロケーション: | Mitochondrion |
計算された分子量: | 81kDa |
観察された分子量: | 81kDa |
同義語: | MTIF2 |
バックグラウンド: | During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. |
UniProt Protein Function: | MTIF2: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. Belongs to the IF-2 family. |
UniProt Protein Details: | Protein type:Translation; Translation initiation; Mitochondrial Chromosomal Location of Human Ortholog: 2p16.1 Cellular Component: mitochondrion; nucleoplasm Molecular Function:GTPase activity; ribosomal small subunit binding; translation factor activity, nucleic acid binding Biological Process: regulation of translational initiation; ribosome disassembly |
NCBI Summary: | During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016] |
UniProt Code: | P46199 |
NCBI GenInfo Identifier: | 223590069 |
NCBI Gene ID: | 4528 |
NCBI Accession: | P46199.2 |
UniProt Secondary Accession: | P46199,D6W5D0, |
UniProt Related Accession: | P46199 |
Molecular Weight: | 81,317 Da |
NCBI Full Name: | Translation initiation factor IF-2, mitochondrial |
NCBI Synonym Full Names: | mitochondrial translational initiation factor 2 |
NCBI Official Symbol: | MTIF2 |
NCBI Protein Information: | translation initiation factor IF-2, mitochondrial |
UniProt Protein Name: | Translation initiation factor IF-2, mitochondrial |
UniProt Gene Name: | MTIF2 |
UniProt Entry Name: | IF2M_HUMAN |
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