Anti-MTHFD2 Antibody (CAB10386)
- SKU:
- CAB10386
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-MTHFD2 Antibody |
抗体コード: | CAB10386 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-250 of human MTHFD2 (NP_006627.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | LO2, U-87MG, HT-29, 293T, DU145, Mouse pancreas |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-250 of human MTHFD2 (NP_006627.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ISGR KLAQ QIKQ EVRQ EVEE WVAS GNKR PHLS VILV GENP ASHS YVLN KTRA AAVV GINS ETIM KPAS ISEE ELLN LINK LNND DNVD GLLV QLPL PEHI DERR ICNA VSPD KDVD GFHV INVG RMCL DQYS MLPA TPWG VWEI IKRT GIPT LGKN VVVA GRSK NVGM PIAM LLHT DGAH ERPG GDAT VTIS HRYT PKEQ LKKH TILA DIV |
遺伝子ID: | 10797 |
Uniprot: | P13995 |
セルラーロケーション: | Mitochondrion |
計算された分子量: | 26kDa/37kDa |
観察された分子量: | 38kDa |
同義語: | MTHFD2, NMDMC |
バックグラウンド: | This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. |
UniProt Protein Function: | MTHFD2: a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009] |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 3.5.4.9; Hydrolase; Oxidoreductase; EC 1.5.1.15; Mitochondrial; Cofactor and Vitamin Metabolism - one carbon pool by folate Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: cytosol; extracellular space; mitochondrial matrix; mitochondrion Molecular Function:formate-tetrahydrofolate ligase activity; magnesium ion binding; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; phosphate binding Biological Process: folic acid metabolic process; one-carbon compound metabolic process; tetrahydrofolate metabolic process |
NCBI Summary: | This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009] |
UniProt Code: | P13995 |
NCBI GenInfo Identifier: | 115311607 |
NCBI Gene ID: | 10797 |
NCBI Accession: | P13995.2 |
UniProt Secondary Accession: | P13995,Q53G90, Q53GV5, Q53S36, Q7Z650, |
UniProt Related Accession: | P13995 |
Molecular Weight: | 26,849 Da |
NCBI Full Name: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
NCBI Synonym Full Names: | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
NCBI Official Symbol: | MTHFD2 |
NCBI Official Synonym Symbols: | NMDMC |
NCBI Protein Information: | bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
UniProt Protein Name: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
Protein Family: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase |
UniProt Gene Name: | MTHFD2 |
UniProt Entry Name: | MTDC_HUMAN |
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