Anti-MTHFD1 Antibody (CAB8661)
- SKU:
- CAB8661
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
抗体名: | Anti-MTHFD1 Antibody |
抗体コード: | CAB8661 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human MTHFD1 (NP_005947.3). |
申し込み: | WB IF |
推奨希釈: | WB 1:200 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Raji, LO2, Mouse brain, Mouse kidney, Rat spinal cord |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human MTHFD1 (NP_005947.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAPA EILN GKEI SAQI RARL KNQV TQLK EQVP GFTP RLAI LQVG NRDD SNLY INVK LKAA EEIG IKAT HIKL PRTT TESE VMKY ITSL NEDS TVHG FLVQ LPLD SENS INTE EVIN AIAP EKDV DGLT SINA GKLA RGDL NDCF IPCT PKGC LELI KETG VPIA GRHA VVVG RSKI VGAP MHDL LLWN NATV TTCH SKTA HLDE EVNK GDIL VVAT GQPE MVKG EWIK PGAI VIDC GINY VPDD KKPN GRKV VGDV AYDE AKER ASFI TP |
遺伝子ID: | 4522 |
Uniprot: | P11586 |
セルラーロケーション: | Cytoplasm |
計算された分子量: | 101kDa |
観察された分子量: | 115kDa |
同義語: | MTHFD1, MTHFC, MTHFD |
バックグラウンド: | This gene encodes a protein that possesses three distinct enzymatic activities, 5, 10-methylenetetrahydrofolate dehydrogenase, 5, 10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. |
UniProt Protein Function: | MTHFD1: an ubiquitous trifunctional enzyme containing two major domains: a N-terminal part, containing methylene-THF dehydrogenase and methenyl-THF cyclohydrolase activities, and a C-terminal part containing a formyl-THF synthetase domain. |
UniProt Protein Details: | Protein type:EC 1.5.1.5; Oxidoreductase; Hydrolase; EC 6.3.4.3; Cofactor and Vitamin Metabolism - one carbon pool by folate; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 3.5.4.9; Ligase Chromosomal Location of Human Ortholog: 14q24 Cellular Component: mitochondrion; membrane; cytosol Molecular Function:methylenetetrahydrofolate dehydrogenase (NADP+) activity; formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity; ATP binding; methylenetetrahydrofolate dehydrogenase activity Biological Process: histidine biosynthetic process; vitamin metabolic process; folic acid and derivative biosynthetic process; methionine biosynthetic process; purine nucleotide biosynthetic process; one-carbon compound metabolic process; folic acid metabolic process; water-soluble vitamin metabolic process Disease: Neural Tube Defects, Folate-sensitive |
NCBI Summary: | This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008] |
UniProt Code: | P11586 |
NCBI GenInfo Identifier: | 38014238 |
NCBI Gene ID: | 4522 |
NCBI Accession: | AAH01014.2 |
UniProt Secondary Accession: | P11586,Q86VC9, Q9BVP5, B2R5Y2, |
UniProt Related Accession: | P11586 |
Molecular Weight: | 101,559 Da |
NCBI Full Name: | MTHFD1 protein, partial |
NCBI Synonym Full Names: | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase |
NCBI Official Symbol: | MTHFD1 |
NCBI Official Synonym Symbols: | MTHFC; MTHFD |
NCBI Protein Information: | C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase; cytoplasmic C-1-tetrahydrofolate synthase; 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase |
UniProt Protein Name: | C-1-tetrahydrofolate synthase, cytoplasmic |
UniProt Gene Name: | MTHFD1 |
UniProt Entry Name: | C1TC_HUMAN |