Anti-MASTL Antibody (CAB14294)
- SKU:
- CAB14294
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
抗体名: | Anti-MASTL Antibody |
抗体コード: | CAB14294 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 580-879 of human MASTL (NP_001165774.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse kidney, Mouse liver, Rat testis, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 580-879 of human MASTL (NP_001165774.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ESPL ESQP LDSD RSIK ESSF EESN IEDP LIVT PDCQ EKTS PKGV ENPA VQES NQKM LGPP LEVL KTLA SKRN AVAF RSFN SHIN ASNN SEPS RMNM TSLD AMDI SCAY SGSY PMAI TPTQ KRRS CMPH QQTP NQIK SGTP YRTP KSVR RGVA PVDD GRIL GTPD YLAP ELLL GRAH GPAV DWWA LGVC LFEF LTGI PPFN DETP QQVF QNIL KRDI PWPE GEEK LSDN AQSA VEIL LTID DTKR AGMK ELKR HPLF SDVD WENL QHQT MPFI PQPD DETD TSYF EARN TAQH LTVS GFSL |
遺伝子ID: | 84930 |
Uniprot: | Q96GX5 |
セルラーロケーション: | Cleavage furrow, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center |
計算された分子量: | 92kDa/97kDa |
観察された分子量: | 110kDa |
同義語: | MASTL, GREATWALL, GW, GWL, MAST-L, THC2 |
バックグラウンド: | This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. |
UniProt Protein Function: | MASTL: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. Defects in MASTL are the cause of thrombocytopenia type 2 (THC2). Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protein kinase, AGC; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; AGC group; MAST family Chromosomal Location of Human Ortholog: 10p12.1 Cellular Component: nucleoplasm; centrosome; cytoplasm; nucleus; cleavage furrow Molecular Function:protein serine/threonine kinase activity; protein phosphatase 2A binding; kinase activity; ATP binding Biological Process: mitosis; regulation of cell cycle; cell division; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of protein phosphatase type 2A activity; protein amino acid phosphorylation; response to DNA damage stimulus Disease: Thrombocytopenia 2 |
NCBI Summary: | This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010] |
UniProt Code: | Q96GX5 |
NCBI GenInfo Identifier: | 288806587 |
NCBI Gene ID: | 84930 |
NCBI Accession: | NP_001165774.1 |
UniProt Secondary Accession: | Q96GX5,Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5, |
UniProt Related Accession: | Q96GX5 |
Molecular Weight: | 97,319 Da |
NCBI Full Name: | serine/threonine-protein kinase greatwall isoform 1 |
NCBI Synonym Full Names: | microtubule associated serine/threonine kinase-like |
NCBI Official Symbol: | MASTL |
NCBI Official Synonym Symbols: | GW; GWL; THC2; hGWL; MAST-L; GREATWALL; RP11-85G18.2 |
NCBI Protein Information: | serine/threonine-protein kinase greatwall; greatwall protein kinase; microtubule-associated serine/threonine-protein kinase-like |
UniProt Protein Name: | Serine/threonine-protein kinase greatwall |
UniProt Synonym Protein Names: | Microtubule-associated serine/threonine-protein kinase-like |
UniProt Gene Name: | MASTL |
UniProt Entry Name: | GWL_HUMAN |
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